The Detroit Tigers host the San Diego Padres in the first game of a three-game set between division leaders tonight at Comerica Park.
The Padres currently own baseball’s best record at 16-6, though five of those losses have come on the road.
Our Padres vs Tigers predictions and MLB picks expect San Diego to ultimately own the pitching matchup and keep the score low on Monday, April 21.
Padres vs Tigers prediction
My Padres vs Tigers best bet: Under 8 (-120 at Caesars)
The San Diego Padres are coming off a series loss in Houston, avoiding the sweep with a 3-2 win over the Astros in Sunday night's finale.
Offense has been a struggle for San Diego on the road, averaging just 3.33 runs across their nine away games, despite leading all teams in hitting with a .276 average. Overall, they’ve scored more than three runs in just two of their last five games.
The Padres send Randy Vasquez to the mound. The righty is 1-1 with a 1.74 ERA across four starts. Last time out, he scattered seven hits across five innings, allowing just a single earned run vs. the Cubs.
Before that start, he pitched one-hit ball over five innings, again allowing just the one earned run, to beat the A’s 2-1 for his first win of the season.
The only blemish for the Detroit Tigers in their series with the Royals was the finale, dropping a 4-3 decision in 10 innings. Detroit had outscored KC 16-5 to win the first three games of the series.
The Tigers boast baseball’s third-best ERA at 3.12, limiting teams to a .216 average (seventh) and a 1.14 WHIP (fourth).
They couple that with an above-average offense, tied for 10th in runs scored at 4.55 per game.
Second-year man Keider Montero will make just his second start of the year, hoping to bounce back from a rough loss against Milwaukee, when he went five innings, giving up three homers and five earned runs in a 5-1 loss.
San Diego offers him a softer landing spot, as it's gone Under the total in seven of its last 10. Detroit has seen the Under go 6-3-1 in its last 10, too, leaving us to stick with the Under in the series opener.
Caesars QuickPick: Our Padres vs Tigers same-game parlay (SGP)
Under 8
Fernando Tatis Jr. Over 1.5 hits
Randy Vasquez Under 3.5 strikeouts
Fernando Tatis Jr. has been hot to start the season, hitting .351, the seventh-best average in baseball. Tatis picked up two hits in Sunday's win over Houston, including his seventh home run of the season.
He’s now gone none straight games with a hit, and has seven multi-hit games in April.
He’s had just three at-bats vs Montero, but does have a hit off him. Look for Tatis to stay hot in the opener.
We’ll wrap with Vasquez, who, despite the solid statistics, hasn’t been a strikeout guy. In four straight starts to the year, the righty has yet to strike out four batters in a single start.
Going back to last season, he’s only had four strikeouts twice in his last 11 starts.
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Padres vs Tigers odds
Padres vs Tigers live odds
Padres vs Tigers opening odds
- Moneyline: San Diego +110 | Detroit -130
- Run line: San Diego +1.5 (-189) | Detroit -1.5 (+158)
- Over/Under: Over 8.5 (-105) | Under 8.5 (-115)
Odds courtesy of Caesars.
Padres vs Tigers trend
The Detroit Tigers have hit the Game Total Under in 44 of their last 82 games at home (+6.80 Units / 8% ROI). Find more MLB betting trends for Padres vs. Tigers.
How to watch Padres vs Tigers and game info
| Location | Comerica Park, Detroit, MI |
| Date | Monday, 4-21-2025 |
| First pitch | 6:40 p.m. ET |
| TV | FS1 |
| Padres starting pitcher | Randy Vasquez (1-1, 1.74 ERA) |
| Tigers starting pitcher | Keider Montero (0-1, 9.00 ERA) |
Padres vs Tigers latest injuries
Padres vs Tigers weather
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