With the First Four now behind us, the March Madness odds are officially set for every Round 1 matchup.
We've got the latest odds for each of those 32 matchups, with no shortage of intrigue for potential Cinderellas, teams looking to turn First Four wins into deep tournament runs, and favorites looking to take care of business.
First Round Odds Thursday, March 20 (early games)
The early slate of Thursday's games features No. 1 seeds Houston and Auburn, both around 30-point favorites, along with popular upset picks High Point (vs. Purdue) and McNeese (vs. Clemson).
Creighton vs. Louisville odds
12:15 p.m. ET | Lexington, KY | CBS
- Spread: Creighton +2.5 (-110) | Louisville -2.5 (-110)
- Total: Over 145.5 (-110) | Under 145.5 (-110)
- Moneyline: Creighton +125 | Louisville -150
High Point vs. Purdue odds
12:40 p.m. ET | Providence, RI | truTV
- Spread: High Point +7.5 (-105) | Purdue -7.5 (-115)
- Total: Over 153.5 (-110) | Under 153.5 (-110)
- Moneyline: High Point +290 | Purdue -370
Montana vs. Wisconsin odds
1:30 p.m. ET | Denver, CO | TNT
- Spread: Montana +17.0 (-110) | Wisconsin -17.0 (-110)
- Total: Over 152.0 (-110) | Under 152.0 (-110)
- Moneyline: Montana +1200 | Wisconsin -2400
SIU Edwardsville vs. Houston odds
2:00 p.m. ET| Wichita, KS | TBS
- Spread: SIU Edwardsville +29.0 (-110) | Houston -29.0 (-110)
- Total: Over 126.5 (-110) | Under 126.5 (-110)
- Moneyline: SIU Edwardsville +2500 | Houston -10000
Alabama State vs. Auburn odds
2:50 p.m. ET | Lexington, KY | CBS
- Spread: Alabama State +32.0 (-110) | Auburn -32.0 (-110)
- Total: Over 150.5 (-110) | Under 150.5 (-110)
- Moneyline: Locked
McNeese vs. Clemson odds
3:15 p.m. ET | Providence, RI | truTV
- Spread: McNeese +7.5 (-110) | Clemson -7.5 (-110)
- Total: Over 134.0 (-110) | Under 134.0 (-110)
- Moneyline: McNeese +275 | Clemson -350
VCU vs. BYU odds
4:05 p.m. ET | Denver, CO | TNT
- Spread: VCU +3.0 (-110) | BYU -3.0 (-110)
- Total: Over 146.0 (-110) | Under 146.0 (-110)
- Moneyline: VCU +130 | BYU -155
Georgia vs. Gonzaga odds
4:35 p.m. ET | Wichita, KS | TBS
- Spread: Georgia +6.5 (-110) | Gonzaga -6.5 (-110)
- Total: Over 150.5 (-110) | Under 150.5 (-110)
- Moneyline: Georgia +235 | Gonzaga -290
More college basketball odds from Covers
First Round odds for Thursday, March 20 (late games)
Thursday's evening session features a couple of No. 2 seeds (Tennessee and St. John's), as well as upset alert games in Yale vs. Texas A&M, Drake vs. Missouri, and UC San Diego vs. Michigan.
Wofford vs. Tennessee odds
6:50 p.m. ET | Lexington, KY | TNT
- Spread: Wofford +19.0 (-110) | Tennessee -19.0 (-110)
- Total: Over 133.0 (-110) | Under 133.0 (-110)
- Moneyline: Wofford +1400 | Tennessee -3000
Arkansas vs. Kansas odds
7:10 p.m. ET | Providence, RI | CBS
- Spread: Arkansas +5.0 (-110) | Kansas -5.0 (-110)
- Total: Over 145.5 (-110) | Under 145.5 (-110)
- Moneyline: Arkansas +180 | Kansas -220
Yale vs. Texas A&M odds
7:25 p.m. ET | Denver, CO | TBS
- Spread: Yale +7.5 (-110) | Texas A&M -7.5 (-110)
- Total: Over 139.0 (-110) | Under 139.0 (-110)
- Moneyline: Yale +265 | Texas A&M -330
Drake vs. Missouri odds
7:35 p.m. ET | Wichita, KS | truTV
- Spread: Drake +6.5 (-110) | Missouri -6.5 (-110)
- Total: Over 132.0 (-110) | Under 132.0 (-110)
- Moneyline: Drake +220 | Missouri -270
Utah State vs. UCLA odds
9:25 p.m. ET | Lexington, KY | TNT
- Spread: Utah State +5.5 (-110) | UCLA -5.5 (-110)
- Total: Over 143.5 (-110) | Under 143.5 (-110)
- Moneyline: Utah State +200 | UCLA -245
Omaha vs. St. John's odds
9:45 p.m. ET | Providence, RI | CBS
- Spread: Omaha +18.5 (-110) | St. John's -18.5 (-110)
- Total: Over 148.0 (-110) | Under 148.0 (-110)
- Moneyline: Omaha +1500 | St. John's -3500
UC San Diego vs. Michigan odds
10:00 p.m. ET |Denver, CO | TBS
- Spread: UC San Diego +2.5 (-110) | Michigan -2.5 (-110)
- Total: Over 142.5 (-110) | Under 142.5 (-110)
- Moneyline: UC San Diego +125 | Michigan -150
UNC Wilmington vs. Texas Tech odds
10:10 p.m. ET | Wichita, KS | truTV
- Spread: UNC Wilmington +14.5 (-110) | Texas Tech -14.5 (-110)
- Total: Over 142.5 (-110) | Under 142.5 (-110)
- Moneyline: UNC Wilmington +950 | Texas Tech -1700
Expert March Madness picks
Looking for the best bets to make this March? Covers has you, well, covered with all our free expert March Madness picks — from Round 1 to the National Championship!
First Round odds for Friday, March 21 (early games)
Both ends of the Tobacco Road rivalry are in action during Friday's early schedule, with Duke and North Carolina both looking to deliver as favorites. There's also No. 12 Colorado State — which is favored over No. 5 Memphis — but no expected "Giant Killer" matchups.
Baylor vs. Mississippi State odds
12:15 p.m. ET | Raleigh, NC | CBS
- Spread: Baylor +1.0 (-110) | Mississippi State -1.0 (-110)
- Total: Over 144.5 (-110) | Under 144.5 (-110)
- Moneyline: Baylor +100 | Mississippi State -120
Robert Morris vs. Alabama odds
12:40 p.m. ET | Cleveland, OH | truTV
- Spread: Robert Morris +23.5 (-110) | Alabama -23.5 (-110)
- Total: Over 165.5 (-110) | Under 165.5 (-110)
- Moneyline: Robert Morris +1800 | Alabama -8000
Lipscomb vs. Iowa State odds
1:30 p.m. ET | Milwaukee, WI | TNT
- Spread: Lipscomb +15.0 (-110) | Iowa State -15.0 (-110)
- Total: Over 143.0 (-110) | Under 143.0 (-110)
- Moneyline: Lipscomb +850 | Iowa State -1400
Colorado State vs. Memphis odds
2:00 p.m. ET | Seattle, WA | TBS
- Spread: Colorado State -2.0 (-110) | Memphis +2.0 (-110)
- Total: Over 147.5 (-110) | Under 147.5 (-110)
- Moneyline: Colorado State -130 | Memphis +110
Mount St. Mary's vs. Duke odds
2:50 p.m. ET | Raleigh, NC | CBS
- Spread: Mount St. Mary's +32.5 (-110) | Duke -32.5 (-110)
- Total: Over 141.0 (-110) | Under 141.0 (-110)
- Moneyline: Mount St. Mary's OTB | Duke OTB
Vanderbilt vs. Saint Mary's odds
3:15 p.m. ET | Cleveland, OH | truTV
- Spread: Vanderbilt +4.5 (-115) | Saint Mary's -4.5 (-105)
- Total: Over 135.5 (-110) | Under 135.5 (-110)
- Moneyline: Vanderbilt +155 | Saint Mary's -185
North Carolina vs. Mississippi odds
4:05 p.m. ET | Milwaukee, WI | TNT
- Spread: North Carolina -1.5 (-115) | Ole Miss +1.5 (-105)
- Total: Over 156.0 (-110) | Under 156.0 (-110)
- Moneyline: North Carolina -130 | Ole Miss +110
Grand Canyon vs. Maryland odds
4:35 p.m. ET | Seattle, WA | TBS
- Spread: Grand Canyon +10.5 (-110) | Maryland -10.5 (-110)
- Total: Over 150.0 (-110) | Under 150.0 (-110)
- Moneyline: Grand Canyon +450 | Maryland -600
More March Madness picks from Covers
- Three underdogs to bet in Round 1
- Score predictions for every Round 1 game
- March Madness by the numbers
- Biggest upsets in March Madness history
First Round odds for Friday, March 21 (late games)
The final session for Round 1 is highlighted by defending champion UConn facing Oklahoma, plus blue bloods in Florida, Michigan State, and Kentucky playing — plus Arizona, which is the biggest upset alert game vs. Akron.
Norfolk State vs. Florida odds
6:50 p.m. ET | Raleigh, NC | TNT
- Spread: Norfolk State +28.5 (-110) | Florida -28.5 (-110)
- Total: Over 154.0 (-110) | Under 154.0 (-110)
- Moneyline: Norfolk State +2500 | Florida -10000
Troy vs. Kentucky odds
7:10 p.m. | Milwaukee, WI | CBS
- Spread: Troy +11.5 (-110) | Kentucky -11.5 (-110)
- Total: Over 152.0 (-110) | Under 152.0 (-110)
- Moneyline: Troy +550 | Kentucky -800
New Mexico vs. Marquette odds
7:25 p.m. ET | Cleveland, OH | TBS
- Spread: New Mexico +4.0 (-110) | Marquette -4.0 (-110)
- Total: Over 153.0 (-110) | Under 153.0 (-110)
- Moneyline: New Mexico +145 | Marquette -170
Akron vs. Arizona odds
7:35 p.m. ET | Seattle, WA | truTV
- Spread: Akron +14.5 (-110) | Arizona -14.5 (-110)
- Total: Over 166.5 (-110) | Under 166.5 (-110)
- Moneyline: Akron +750 | Arizona -1200
Oklahoma vs. UConn odds
9:25 p.m. ET | Raleigh, NC | TNT
- Spread: Oklahoma +5.0 (-110) | UConn -5.0 (-110)
- Total: Over 147.5 (-110) | Under 147.5 (-110)
- Moneyline: Oklahoma +180 | UConn -220
Xavier vs. Illinois odds
9:45 p.m. ET | Milwaukee, WI | CBS
- Spread: TBD
- Total: TBD
- Moneyline: TBD
Bryant vs. Michigan State odds
10:00 p.m. ET | Cleveland, OH | TBS
- Spread: Bryant +17.5 (-110) | Michigan State -17.5 (-110)
- Total: Over 152.5 (-110) | Under 152.5 (-110)
- Moneyline: Bryant +1250 | Michigan State -2500
Liberty vs. Oregon odds
10:10 p.m. ET | Seattle, WA | truTV
- Spread: Liberty +7.0 (-110) | Oregon -7.0 (-110)
- Total: Over 139.5 (-110) | Under 139.5 (-110)
- Moneyline: Liberty +260 | Oregon -320
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