Today's Best March Madness Parlay: March 22

While Round 1 didn't have a flurry of notable upsets, that could change during Saturday's second-round action. We're specifically eyeing UCLA and Gonzaga in our March Madness parlay.

Jeremy Jones - Betting Analyst at Covers
Jeremy Jones • Betting Analyst
Mar 22, 2025 • 09:06 ET • 4 min read
Tyler Bilodeau UCLA Bruins Big Ten college basketball
Photo By - Imagn Images. UCLA Bruins forward Tyler Bilodeau.

It was an eventful first round for March Madness betting, but with few upsets. However, I can see that shifting as we enter Round 2. 

My three-leg parlay is focusing on the final three games of the night. These are my best March Madness picks for Saturday, March 22.

Today’s best March Madness parlay: Saturday, March 22

Wisconsin -1

Gonzaga +5.5

UCLA +5

Wisconsin -1

These two teams have very similar styles, except the Wisconsin Badgers are much more talented. The Badgers also have a better defense and shoot better from the free-throw line. Wisconsin leads the country with an 82.7% shooting percentage from the charity stripe. 

The BYU Cougars struggle from the free-throw line and give up a ton of threes. That may be all the difference the Badgers need to advance to the Sweet 16. 

Gonzaga +5.5

The Gonzaga Bulldogs were very likely underseeded as a No. 8. They're ranked ninth in the KenPom rankings, including ninth in offensive efficiency and 29th in defensive efficiency. They certainly looked the part on Thursday when they dismantled Georgia. 

The Houston Cougars are the most vulnerable No. 1 seed because they can struggle offensively in certain situations. They have the best defense in the country, but Gonzaga shoots the second-best percentage in the nation. I like Gonzaga to win outright, but I'll take the points here. 

UCLA +5

The UCLA Bruins looked like the team ranked 15th in the country entering 2025 on Thursday night when they beat Utah State 72-47. This team has wins over Oregon, Wisconsin, Arizona, and Michigan State, so they won't be intimidated by the No. 2-seeded Tennessee Volunteers.  

Both teams are excellent on the defensive end and play at a slow pace. That is why I like taking the points. I would lean towards a UCLA upset, but I especially like the spread in what should be a close game.

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Jeremy Jones - Covers
Betting Analyst

Jeremy Jones was born and raised in Lexington, Kentucky and has been a massive Wildcats fans since the moment he came into the world. He wrote his first sports article at the tender age of 11 after attending a local AHL hockey game, and a few years later was writing professionally for sites such as Sports Rants, BetAmerica, and TwinSpires.

Jeremy holds a Masters in Sports Administration from Eastern Kentucky University and utilizes all seven betting options available in Kentucky to shop for odds and promos and find the greatest EV in every wager he places.

His best piece of sports betting advice is to stick to consistent unit sizes for every wager. He acknowledges there will occasionally be a bet that has a huge EV and you can play multiple units in one bet, but cautions against raising your unit size, because you can quickly lose all your winnings if you hit a minor cold streak.

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