Indiana vs Wyoming East Region Picks: Hoosiers Humble Sliding Cowboys

When these two teams meet, they'll be playing for a spot in March Madness. With the Cowboys stinking it up of late, we're riding the Hoosiers to cover the college basketball betting spread in our Indiana vs. Wyoming picks and predictions.

Rohit Ponnaiya - Betting Analyst at Covers.com
Rohit Ponnaiya • Betting Analyst
Mar 15, 2022 • 19:30 ET • 4 min read
Trayce Jackson-Davis Indiana Hoosiers NCAA First Four
Photo By - USA TODAY Sports

The Indiana Hoosiers take on the Wyoming Cowboys in the first game of the First Four portion of the NCAA Tournament tonight.

The Hoosiers must be a tad disappointed to be in this position given how close they were to making the Big Ten finals but oddsmakers expect them to advance to the first round with March Madness odds opening with Indiana as a 4-point favorite. 

Here are our free March Madness picks and predictions for Indiana vs. Wyoming on Tuesday, March 14, with tipoff at 9:10 p.m. ET.

Indiana vs Wyoming odds

This odds widget represents the best odds available for each betting market from regulated sportsbooks.

This line hit the board with the Hoosiers installed as 4-point favorites with the Over/Under at 132.5. As of 2 p.m. ET on Monday afternoon the spread and total haven't seen movement.

Use the live odds widget above to track any future line movements right up until tip-off and be sure to check out the full college basketball odds before placing your bets.

Indiana vs Wyoming predictions

Predictions made on 3/14/2022 at 2 p.m. ET.
Click on each prediction to jump to the full analysis.

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Indiana vs Wyoming game info

Location: UD Arena, Dayton, OH
Date: Tuesday, March 15, 2022
Tip-off: 9:10 p.m. ET
TV: truTV

Indiana vs Wyoming betting preview

Injuries

Indiana: Khristian Lander G (Questionable), Logan Duncombe C (Questionable), Jordan Geronimo F (Questionable).
Wyoming: Kenny Foster G (Out).
Find our latest NCAA basketball injury reports.

Betting trend to know

The Hoosiers are 13-6 ATS in their last 19 games as a favorite. Find more NCAA betting trends for Indiana vs. Wyoming.

Indiana vs Wyoming picks and predictions

Our side and total predictions are based upon our analysis of the line and total in this game. Our best bet is our favorite pick across all markets.

Spread analysis

The Hoosiers stumbled into the Big Ten Tournament losing two of their last nine regular-season games and going 3-6 against the spread during that span. But they looked sharp in the tourney upsetting Michigan and Illinois in back-to-back days before losing to the Hawkeyes on a last-second 3-pointer banked in by Jordan Bohannon. 

Indiana has been inconsistent on offense but has a few nice scoring options including Trayce Jackson-Davis who leads the team with 18.1 points, 8.2 rebounds, and 2.4 blocks per game.

It has been much more impressive on the other end of the floor where it ranks 21st in the country in adjusted defensive efficiency according to KenPom and holds foes to a 39.1 FG% — the fifth-best mark among all Power Six programs. 

Wyoming is coming off a 68-61 loss to Boise State in the Mountain West semifinals on Friday. The Cowboys went 12-1 straight up (8-5 ATS) over a 13-game stretch from December 23 to February 12, but then the wheels fell off.

They are 4-5 SU and 3-6 ATS in their last nine games and despite boasting two of the best offensive players in the Mountain West in Graham Ike (19.6 ppg, 9.6 rpg) and Hunter Maldonado (18.4 ppg, 6.3 apg) they have struggled to put points on the board. 

Big Ten play throughout the season was a bit rocky for the Hoosiers but they played well against out-of-conference foes and impressed against highly ranked Purdue, beating the Boilermakers in Bloomington and taking them down to the wire on the road.

With how well they have played lately (especially defensively) they should be able to lock down the Cowboys and cover this spread. 

Prediction: Indiana -4 (-110)

Over/Under analysis

The Hoosiers are holding opponents to 65.9 points per game and have allowed fewer than 70 points in four of their last five contests. That's bad news for a Cowboys team that is averaging just 60 ppg in regulation over its last five games while shooting a pathetic 38.2% from the field.

Both of these teams also play at a modest pace and neither takes many attempts from deep with Wyoming ranking outside the Top-150 teams in the country with 7.5 3-pointers per game and Indiana averaging just 6.1. 

With the Under 5-2 in Wyoming's last seven games, we're leaning towards the Under on Tuesday.

Prediction: Under 132.5 (-110)

Best bet

The Hoosiers come into the NCAA Tournament playing some of their best ball of the year while the Cowboys are fresh off several disappointing performances. Wyoming's shooting has been especially troubling in recent weeks and now it takes on an Indiana team with defensive versatility and lockdown ability.

That's more than enough for us to back a Big Ten school against a Mountain West program that has gone just 1-4 ATS in its last five games versus a team with a winning record. 

Pick: Indiana -4 (-110)

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Betting Analyst

With a background playing soccer, rugby, and boxing, combined with a journalism degree, it's little surprise that Rohit gravitated towards the world of sports betting. He specializes in betting on UFC and college basketball, two sports where the eyeball test can tell you a lot more about matchups than any analytics. Rohit has years of experience handicapping NFL and NBA games as well as niche betting markets such as politics and Oscar odds. He's also the resident CFL expert and formerly hosted "The Chez and Ro Show" with former CFL star Davis Sanchez.

You can catch Rohit breaking down every UFC event with Joe Osborne on "P4P Picks" on the Covers YouTube channel and he also has regular appearances on "Before You Bet" with Joe. In addition, he's a regular guest on "By The Book" on the Monumental Sports Network and makes guest appearances on VSIN's "The Handle" and CBS Sports.

Rohit primarily makes his bets at bet365, which offers a wide variety of prop markets, but also has accounts at several others so he can shop around for the best prices. For Rohit, bankroll management is key. He believes you should never bet what you can't afford to lose and maximize those few betting opportunities where books misprice a line.

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