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The Big Dance is officially underway, with Day 1 in the books — and now we're looking at the March Madness odds for every one of Friday's Round 1 matchups.
We've got the latest odds for each of those 16 games, and after McNeese and Drake pulled off upsets on Thursday, we'll see who will defy (or deliver) on their pre-game lines today.
First Round odds for Friday, March 21 (early games)
Both ends of the Tobacco Road rivalry are in action during Friday's early schedule, with Duke and North Carolina both looking to deliver as favorites. There's also No. 12 Colorado State — which is favored over No. 5 Memphis — but no expected "Giant Killer" matchups.
Baylor vs. Mississippi State odds
12:15 p.m. ET | Raleigh, NC | CBS
- Spread: Baylor +1.5 (-105) | Mississippi State -1.5 (-115)
- Total: Over 145.0 (-110) | Under 145.0 (-110)
- Moneyline: Baylor +105 | Mississippi State -125
Robert Morris vs. Alabama odds
12:40 p.m. ET | Cleveland, OH | truTV
- Spread: Robert Morris +22 (-110) | Alabama -22 (-110)
- Total: Over 166.0 (-110) | Under 166.0 (-110)
- Moneyline: Robert Morris +1800 | Alabama -8000
Lipscomb vs. Iowa State odds
1:30 p.m. ET | Milwaukee, WI | TNT
- Spread: Lipscomb +14.5 (-110) | Iowa State -14.5 (-110)
- Total: Over 143.0 (-110) | Under 143.0 (-110)
- Moneyline: Lipscomb +850 | Iowa State -1400
Colorado State vs. Memphis odds
2:00 p.m. ET | Seattle, WA | TBS
- Spread: Colorado State -1.5 (-110) | Memphis +1.5 (-110)
- Total: Over 147.0 (-110) | Under 147.0 (-110)
- Moneyline: Colorado State -120 | Memphis +100
More college basketball odds from Covers
Mount St. Mary's vs. Duke odds
2:50 p.m. ET | Raleigh, NC | CBS
- Spread: Mount St. Mary's +32.0 (-110) | Duke -32.0 (-110)
- Total: Over 140.5 (-110) | Under 140.5 (-110)
- Moneyline: Mount St. Mary's +2800 | Duke -20000
Vanderbilt vs. Saint Mary's odds
3:15 p.m. ET | Cleveland, OH | truTV
- Spread: Vanderbilt +4.5 (-115) | Saint Mary's -4.5 (-105)
- Total: Over 135.5 (-110) | Under 135.5 (-110)
- Moneyline: Vanderbilt +165 | Saint Mary's -200
North Carolina vs. Mississippi odds
4:05 p.m. ET | Milwaukee, WI | TNT
- Spread: North Carolina -2.0 (-105) | Mississippi +2.0 (-115)
- Total: Over 155.5 (-110) | Under 155.5 (-110)
- Moneyline: North Carolina -130 | Ole Miss +110
Grand Canyon vs. Maryland odds
4:35 p.m. ET | Seattle, WA | TBS
- Spread: Grand Canyon +10.0 (-105) | Maryland -10.0 (-115)
- Total: Over 150.0 (-110) | Under 150.0 (-110)
- Moneyline: Grand Canyon +400 | Maryland -550
Expert March Madness picks
Looking for the best bets to make this March? Covers has you, well, covered with all our free expert March Madness picks — from Round 1 to the National Championship!
First Round odds for Friday, March 21 (late games)
The final session for Round 1 is highlighted by defending champion UConn facing Oklahoma, plus blue bloods in Florida, Michigan State, and Kentucky playing — plus Arizona, which is the biggest upset alert game vs. Akron.
Norfolk State vs. Florida odds
6:50 p.m. ET | Raleigh, NC | TNT
- Spread: Norfolk State +28.5 (-110) | Florida -28.5 (-110)
- Total: Over 153.5 (-110) | Under 153.5 (-110)
- Moneyline: Norfolk State +2800 | Florida -20000
Troy vs. Kentucky odds
7:10 p.m. | Milwaukee, WI | CBS
- Spread: Troy +11.5 (-110) | Kentucky -11.5 (-110)
- Total: Over 151.5 (-110) | Under 151.5 (-110)
- Moneyline: Troy +525 | Kentucky -750
New Mexico vs. Marquette odds
7:25 p.m. ET | Cleveland, OH | TBS
- Spread: New Mexico +4.0 (-110) | Marquette -4.0 (-110)
- Total: Over 152.5 (-110) | Under 152.5 (-110)
- Moneyline: New Mexico +150 | Marquette -180
Akron vs. Arizona odds
7:35 p.m. ET | Seattle, WA | truTV
- Spread: Akron +14.5 (-110) | Arizona -14.5 (-110)
- Total: Over 167.5 (-110) | Under 167.5 (-110)
- Moneyline: Akron +750 | Arizona -1200
More March Madness picks from Covers
- Three underdogs to bet in Round 1
- Score predictions for every Round 1 game
- March Madness Survivor picks
- March Madness by the numbers
- Biggest upsets in March Madness history
Oklahoma vs. UConn odds
9:25 p.m. ET | Raleigh, NC | TNT
- Spread: Oklahoma +5.5 (-105) | UConn -5.5 (-115)
- Total: Over 148.5 (-110) | Under 148.5 (-110)
- Moneyline: Oklahoma +195 | UConn -240
Xavier vs. Illinois odds
9:45 p.m. ET | Milwaukee, WI | CBS
- Spread: Xavier +3.0 (-110) | Illinois -3.0 (-110)
- Total: Over 161.0 (-110) | Under 161.0 (-110)
- Moneyline: Xavier +130 | Illinois -155
Bryant vs. Michigan State odds
10:00 p.m. ET | Cleveland, OH | TBS
- Spread: Bryant +17.0 (-110) | Michigan State -17.0 (-110)
- Total: Over 152.5 (-110) | Under 152.5 (-110)
- Moneyline: Bryant +1100 | Michigan State -2200
Liberty vs. Oregon odds
10:10 p.m. ET | Seattle, WA | truTV
- Spread: Liberty +7.0 (-115) | Oregon -7.0 (-105)
- Total: Over 139.0 (-110) | Under 139.0 (-110)
- Moneyline: Liberty +250 | Oregon -310
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