March Madness Odds For Today's NCAA Tournament Second Round Games: Sunday, March 23

Today concludes the opening weekend of the NCAA Tournament, with the other half of the bracket looking to punch their tickets to the Sweet 16 — and extend their March Madness odds for a few more days.

We've got the latest odds for today's Second Round games, including some high-profile matchups and Cinderellas looking to reach the Sweet 16.

Second Round odds for Saturday, March 22 (early games)

The early slate starts with two-time defending champion UConn looking to upset No. 1 Florida, plus Cooper Flagg and Duke in action against Baylor.

UConn vs Florida odds

12:10 p.m. ET | Lenovo Center, Raleigh, NC | CBS

• Spread: UConn +9.5 (-110) | Florida -9.5 (-110)

• Total: Over 150.5 (-110) | Under 150.5 (-110)

• Moneyline: UConn +400 | Florida -555

Baylor vs Duke odds

2:40 p.m. ET | Lenovo Center, Raleigh, NC | CBS

• Spread: Baylor +12.5 (-110) | Duke -12.5 (-110)

• Total: Over 144.0 (-110) | Under 144.0 (-110)

• Moneyline: Baylor +650 | Duke -1000

Illinois vs Kentucky odds

5:15 p.m. ET | Fiserv Forum, Milwaukee, WI | CBS

• Spread: Illinois -2.0 (-115) | Kentucky +2.0 (-105)

• Total: Over 170.0 (-110) | Under 170.0 (-110)

• Moneyline: Illinois -135 | Kentucky +115

Saint Mary's vs Alabama odds

6:10 p.m. ET | Rocket Arena, Cleveland, OH | TNT

• Spread: Saint Mary's +5.5 (-105) | Alabama -5.5 (-115)

• Total: Over 149.5 (-110) | Under 149.5 (-110)

• Moneyline: Saint Mary's +195 | Alabama -240

Second Round odds for Saturday, March 22 (late games)

Today's late session is highlighted by two double-digit seeds in action, with No. 12 Colorado State facing Maryland and No. 10 New Mexico looking to upset second-seeded Michigan State.

Colorado State vs Maryland odds

7:10 p.m. ET | Climate Pledge Arena, Seattle, WA | TBS

• Spread: Colorado State +7.5 (-105) | Maryland -7.5 (-115)

• Total: Over 143.0 (-110) | Under 143.0 (-110)

• Moneyline: Colorado State +275 | Maryland -350

Mississippi vs Iowa State odds

7:45 p.m. ET | Fiserv Forum, Milwaukee, WI | truTV

• Spread: Mississippi +5.5 (-110) | Iowa State -5.5 (-110)

• Total: Over 145.5 (-110) | Under 145.5 (-110)

• Moneyline: Mississippi +190 | Iowa State -230

New Mexico vs Michigan State odds

8:40 p.m. ET | Rocket Arena, Cleveland, OH | TNT

• Spread: New Mexico +7.5 (-110) | Michigan State -7.5 (-110)

• Total: Over 148.0 (-110) | Under 148.0 (-110)

• Moneyline: New Mexico +265 | Michigan State -330

Oregon vs Arizona odds

9:40 p.m. ET | Climate Pledge Arena, Seattle, WA | TBS

• Spread: Oregon +4.0 (-110) | Arizona -4.5 (-110)

• Total: Over 152.5 (-110) | Under 152.5 (-110)

• Moneyline: Oregon +150 | Arizona -180

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