While there are no Top-10 matchups on the Week 11 docket, this week's college football odds should center around two notable SEC showdowns: Georgia-Mississippi and Alabama-LSU.
I give my picks for those games and every other top team in my best Week 11 college football picks below.
College football Week 11 picks against the spread
| Matchup | Pick |
|---|---|
 Purdue vs  Ohio State |
+38 |
 Miami vs  Georgia Tech |
-10.5 |
 Florida vs  Texas |
+21.5 |
 Georgia vs  Mississippi |
+2.5 |
 Michigan vs  Indiana |
-14.5 |
 Colorado vs  Texas Tech |
-3.5 |
 Maryland vs  Oregon |
-25 |
 Alabama vs  LSU |
+2.5 |
 Washington vs  Penn State |
-13.5 |
Lines courtesy of DraftKings as of 11-6.
CFB Week 11 ATS picks
Purdue vs. Ohio State (-38): Purdue +38
Be it a letdown or simply worry about covering a number as gigantic as this one, my instinct is to take the points. Even a 42-7 scoreline won't get the job done.
Miami (-10.5) vs. Georgia Tech: Miami -10.5
Miami has been scraping by for much of the season, but I see this as a spot to find separation and never look back.
Florida vs. Texas (-21.5): Florida +21.5
Quarterback uncertainties noted, Florida was up seven at half at Georgia last week and was tied 20-20 deep into the fourth quarter. Give me the hook on this three-touchdown spread.
Georgia (-2.5) vs. Mississippi: Mississippi +2.5
A win over No. 1 Texas and a No. 2 ranking aside, something doesn't smell right about this Georgia team. This may be the perfect opportunity for that thought to come to life.
Michigan vs. Indiana (-14.5): Indiana -14.5
It's a joy for this Buckeyes fan to watch Michigan's season go up in flames — and that won't change against an undefeated Indiana program that's won its six Big Ten games by an average of 26.7 points.
Colorado (-3.5) vs. Texas Tech: Colorado -3.5
Texas Tech did well to end Iowa State's undefeated campaign but Colorado's playing about as well as anyone could have imagined right now.
Maryland vs. Oregon (-25): Oregon -25
Oregon is playing at a level matched by no other team in the nation. Lay the number.
Alabama (-2.5) vs. LSU: LSU +2.5
Alabama continues to look vulnerable in SEC play and finds itself in one of the nation's toughest places to play Saturday night. I'll take the points.
Washington vs. Penn State (-13.5): Penn State
To remove any playoff doubt, Penn State has no choice but to lay the smackdown on the rest of its schedule, making this an easy choice with the number under two touchdowns.
Not intended for use in MA.
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