After the absolute bloodbath of upsets that came in Week 6, it's time to turn the page to the Week 7 college football odds.
The marquee matchup sees No. 2 Ohio State hitting the highway to take on No. 3 Oregon in Eugene. I pick a winner for that game and much more in my ATS college football picks below.
College football Week 7 picks against the spread
| Matchup | Pick |
|---|---|
 South Carolina vs  Alabama |
+21 |
 Clemson vs  Wake Forest |
-20 |
 Texas vs  Oklahoma |
-14.5 |
 Penn State vs  USC |
+5 |
 Mississippi State vs  Georgia |
+33.5 |
 Florida vs  Tennessee |
+15 |
 Ohio State vs  Oregon |
-3 |
 Mississippi vs  LSU |
-3.5 |
 Kansas State vs  Colorado |
-3.5 |
Lines courtesy of DraftKings as of 10/8.
CFB Week 7 ATS picks
South Carolina vs Alabama (-21): South Carolina +21
What seems like an obvious bounce-back spot for Bama might not be quite as it seems. Despite South Carolina getting rocked by Mississippi last week, this is still an underrated — and now desperate — team in the SEC.
Clemson (-20) vs Wake Forest: Clemson -20
Clemson has now won four straight games by an average of 28 points and is 3-1 ATS over that span. Wake beating NC State is impressive on paper but much less so when you factor in Grayson McCall's injury.
Texas (-14.5) vs Oklahoma: Texas -14.5
There's simply no reason to stop backing the Longhorns, who failed to cover for the first time in Week 5 and will have Quinn Ewers back under center after a bye in Week 6. Lay the number.
Penn State (-5) vs USC: USC +5
It would be easy to lean toward the undefeated Nittany Lions, but I'm happy to take the points with the Trojans inside the Coliseum, where they're 3-0 SU and 3-0 ATS this season.
Mississippi State vs Georgia (-33.5): Mississippi State +33.5
This is a massive number for a Georgia team that has just a +12 point differential in three SEC games this season. Mississippi State held No. 1 Texas to 35 points at home in a 22-point loss two weeks ago (albeit without Quinn Ewers).
Florida vs Tennessee (-15): Florida +15
The sentiment around Tennessee's offense has been flipped on its head over the last two weeks, so much so that covering a three-score spread becomes a much tougher task. For all its flaws, Florida has scored 69 points over its last two wins (vs. UCF, at Miss State).
Ohio State (-3) vs Oregon: Ohio State -3
In by far the game of the week, the Buckeyes are off to Eugene for their first true test. Oregon has shed some of its early-season rust, but this is still a team that's just 1-4 ATS this season. Give me the Buckeyes 31-23.
Mississippi (-3.5) vs LSU: Mississippi -3.5
With LSU high on my list of untrustworthy teams, this is an easy choice. The Rebels dominated South Carolina to get back in the win column, and I expect another encouraging result here.
Kansas State (-3.5) vs Colorado: Kansas State -3.5
Colorado's 48-21 win over UCF is particularly impressive but I expect things to come undone against what might be the best team in the Big 12.
Not intended for use in MA.
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