49ers vs Jaguars Odds, Picks, and Predictions Week 10: Bye Week Helps Both Teams Get Set

The San Fransisco 49ers and Jacksonville Jaguars will both be rested coming out of the bye and at near full health ahead of the Week 10 meeting in Florida where the 49ers sit as a field-goal road favorite with a climbing total.  

With the extra breather and getting both offenses healthier, should bettors be expecting more points in this game considering this NFL odds matchup will feature two of the Top 5 passing offenses in football?

I break down the Week 10 NFL odds and offer my free NFL picks for 49ers vs. Jaguars on November 12. 

49ers vs Jaguars odds

49ers vs Jaguars predictions

The San Francisco 49ers went into the bye having dropped three straight games but the rest will do this offense right as Deebo Samuel will return to the lineup and tackle Trent Williams has a better shot at suiting up after missing the two previous games. He was DNP at practice Wednesday but a late-week limited tag could go a long way in dressing. 

Brock Purdy will be happy with the rest and the return of Deebo. Before the losing skid, this was an offense that had scored at least 30 points in five straight games and had the No.1 passing offense, per success rate. 

Bettors should expect plenty of passing Sunday as the Jacksonville Jaguars have been quietly one of the best rush defenses in football, ranking first in success rate vs. the run on the season. This is a Jacksonville secondary that could also be without starting cornerback Tyson Campbell and safety Andre Cisco, who were both DNP at Wednesday's practice. San Francisco ranks second in football at a sexy 0.452 points per play and could certainly take advantage of a wounded secondary.

The Jags’ passing game will also have a good matchup here. Zay Jones could return after being limited on Wednesday, Calvin Ridley looked much better in Week 8, and Trevor Lawrence’s knee got some rest with the off-week. 

The Jacksonville offense was cooking before the hiatus, averaging 29.3 points per game over its last three and that included 20 points vs. the Steelers in the rain, where it still averaged 7.7 yards per pass but left some points on the field going 0-3 in the red zone. 

The 49ers defense is formidable, especially with the addition of Chase Young, but the Jacksonville O-line will enter Week 10 as healthy as it has been all season. Joe Burrow completed 28 of 32 passes vs. The 49ers in Week 8, and Kirk Cousins completed 78% of his passes vs. this defense for nearly 400 yards the week before that. 

Quarterbacks can beat this secondary, which is why this Over has taken some money, moving it from 44.5 to as high as 45.5. I’m happy to take the Over here up to 46, which is where I think it will move if Williams is active.   

My best bet: Over 45.5 (-110 at bet365)
Picks made at time of writing may not reflect live odds.

49ers vs Jaguars same-game parlay

Over 45.5

Jaguars moneyline

Trevor Lawrence Over 3.5 rushing attempts

+625 at bet365

Give me this Over and give me the Jags to send the 49ers to their fourth straight loss. We could be talking about the Jags being one of the AFC's best after this game. They have a defense that can beat the 49ers, and with the extra time while facing a West Coast team at home, there is quite a lot to like about the Jags in Week 10, especially with the hype of five straight wins (and covers) being lessened thanks to the bye.

With winning comes victory formation, which counts as carries. Lawrence had been running of late even with a hurt knee so the break should certainly help out there. He had just one run in Pittsburgh in the rain but averaged nearly six rushes per game from Weeks 1 to 7. 

Learn how to bet a same-game parlay with these helpful tips and strategies.

49ers vs Jaguars spread and Over/Under analysis

Following the bye last season, Kyle Shanahan and the 49ers went on a solid 11-1 SU to end the season but adding Christian McCaffrey helped, too. They’re currently mired in a three-game losing skid but the break likely helped them more than it did the Jaguars entering this week. Oddsmakers are favoring them this week substantially on the road as a 3-point dog, which was -2.5 on the look-ahead.

The 49ers upgraded their pass rush with the addition of Chase Young improving a defensive front line that might rank in the Top 10 in pressure percentage but with just 18 sacks, ranks in the Bottom 10 in that category. Many people were ready to crown this as the best defense in football early in the season but, since Week 4, this a defense with a worse success rate than the Bears and is giving up 395 yards of offense over its last three games, which ranks 31st in the league over that stretch.

As of Thursday afternoon, there aren’t any 3.5s available but if Trent Williams is a go, this could move to SF -3.5. I like the Jags here at +3 without Williams and even +3.5 with him active. The Jacksonville offense is back on track after a shaky September/early October, which might still be in people’s minds. It’s one of the most underrated defenses in football that doesn’t give QBs much time with a 10% hurry percentage (sixth) and is one of just four teams allowing under 80 rush yards per game. The home side's defense could make the 49ers one-dimensional Sunday and put some pressure on Purdy who has five picks over the three-game losing streak. 

I know Shanahan will get the 49ers back on track, but this is still a team that has lost three in a row outright at -4.5, -6.5, and -8.5. Yes, they’re getting healthier, but so are the Jags who have ripped off five straight games and covered in each. 

49ers vs Jaguars betting trend to know

The Jaguars have hit the Moneyline in 16 of their last 21 games (+11.85 Units / 37% ROI). Find more NFL betting trends for 49ers vs. Jaguars.

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