NFL Week 6 Against the Spread Picks for Every Game

The 49ers travel to Seattle to take on the Seahawks on Thursday Night Football, and our NFL expert Chris Vasile believes the Niners will get you off to a winning start in your ATS pools.

Chris Vasile - Publishing Editor at Covers.com
Chris Vasile • Publishing Editor
Oct 8, 2024 • 16:46 ET • 4 min read
George Kittle San Francisco 49ers NFL
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I am coming off the best week to date in my weekly NFL ATS picks as we went 10-5-1 in Week 5. 

The record, while good in its own right, still only got me second place in my weekly NFL pool, so I vow to do one better and give you at least two more winners this week. 

Join me as I break down my best Week 6 ATS NFL picks below. 

Week 6 picks against the spread

Matchup Pick
49ers 49ers vs Seahawks Seahawks  49ers (-3.5)
Jaguars Jaguars  vs Bears Bears Jaguars (+2.5)
Cardinals Cardinals vs Packers Packers Packers (-5)
Colts Colts vs Titans Titans Colts (-1)
Texans Texans vs Patriots Patriots Texans (-7)
Buccaneers Buccaneers vs Saints Saints Buccaneers (-2.5)
Browns Browns vs Eagles Eagles Eagles (-8.5)
Commanders Commanders vs Ravens Ravens Commanders (+6.5)
Chargers Chargers vs Broncos Broncos  Broncos (+3)
Steelers Steelers vs Raiders Raiders Steelers (-3)
Lions Lions vs Cowboys Cowboys Lions (-3.5)
Falcons Falcons vs Panthers Panthers Falcons (-6.5)
Bengals Bengals vs Giants Giants Giants (+3.5)
Bills Bills vs Jets Jets Bills (-2.5)

Lines courtesy of bet365 as of 10-8

Week 6 ATS picks

49ers vs Seahawks
49ers 49ers -3.5

Sure, the 49ers may have thrown last week's game away with a poor second half, but this is still a team littered with talent on the offensive side of the ball and I'm expecting a bounce-back effort. The Seahawks defense has been shredded over the last two weeks and I don't see them flipping the switch on a short week. 

Jaguars vs Bears
Jaguars Jaguars +2.5

While the Bears were full marks for beating the Panthers, I liked what I saw from the Jaguars for 55 of the 60 minutes vs. Indianapolis. Throw in the fact that the Jags are accustomed to playing in London, and I'll take the points with them in this spot. 

Cardinals vs Packers
Packers Packers -5

This is more a play against the Cardinals than it is a play on the Packers. I'm banking on Arizona suffering a letdown after their comeback win vs. the 49ers last week. The Packers looked good at times vs. the Rams and Jordan Love appears to have shaken the rust off after returning from injury.

Colts vs Titans
Colts Colts -1

Joe Flacco > Will Levis. More so, if they get Jonathan Taylor back, the line will only rise. 

Texans vs Patriots
Texans Texans -7

I wrote a blurb here, then had to delete it because the Patriots announced they were going with Drake Maye. So here's my updated blurb: The Patriots' offense is still JV at best (even with Maye), and the Texans will win this one going away. 

Buccaneers vs Saints
Buccaneers Buccaneers -2.5

There's cause for concern with Derek Carr under center for the Saints, and with Tampa having the rest advantage and a plethora of weapons, they should do enough on the road to win by at least a field goal.

Browns vs Eagles
Eagles Eagles -8.5

No bet against the Browns is a bad bet right now. The Eagles are rested off their bye and at home should dominate this game from start to finish. 

Commanders vs Ravens
CommandersCommanders +6.5

I'm starting to believe in the Commanders and in particular, Jayden Daniels. He should be able to carve up the Ravens' secondary similar to how Joe Burrow did, and the Ravens may have an emotional letdown off an overtime win vs. a division rival.

Chargers vs Broncos
Broncos Broncos +3

Even off a bye, I'm not sure I'm willing to trust the Chargers to pick up a road win of more than a field goal. Both teams rate out evenly on both sides of the football, so I'll take the home dog with a bit of momentum on their side. 

Steelers vs Raiders
Steelers Steelers -3

This is not a game I particularly like, but someone has to win this game. Give me the team with the better defense in this spot. 

Lions vs Cowboys
Lions Lions -3.5

The Cowboys found a way to win on Sunday Night Football, but against any other team with a competent offense, they find no such luck. The Lions are among the best offenses in the league and should have no issues going up and down the field on a weak Cowboys defense. 

Falcons vs Panthers
Falcons Falcons -6.5

The Falcons enter this one with the rest advantage and the better all-around team. Do you trust the Panthers to play their best game of the year? I don't. 

Bengals vs Giants
Giants Giants +3.5

If the Bengals don't blow last week's game vs. Baltimore, I'm taking the Bengals here. However, that didn't play out, and at 1-4, they are all but done from the postseason race this year. The Giants have some momentum, and at home catching more than a field goal, I'll take them to keep it close. 

Bills vs Jets
Bills Bills -2.5

Josh Allen will outplay Aaron Rodgers. Sean McDermott will outcoach [insert Jets interim coach]. The Buffalo Bills will beat the New York Jets. 

Not intended for use in MA.
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Chris Vasile Covers.com
Publishing Editor

Chris Vasile has been in the betting industry for well over a decade honing his craft as a writer, editor and handicapper. A journalism graduate from Conestoga College in Kitchener, Ontario, Chris has contributed betting and non-betting content for online publications such as ProSportsDaily and The Hockey Writers, in addition to Covers. With a keen interest in soccer, Chris has been featured on Covers' 'Before You Bet' and runs his own YouTube channel — Game Day Wagers.

When it comes to daily sports betting, his sportsbook of choice is bet365 for the plethora of markets and great UX. Chris' top sports betting advice is to stick to what you know. Being a jack of all trades and master of none is a quick way to bust the bankroll. Find one or two sports you can devote your time to and trust the process.

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