NFL Picks Against the Spread for Every Week 15 Game

Chris Vasile gives his best NFL picks against the spread for every Week 15 game including Rams vs. 49ers on Thursday Night Football.

Chris Vasile - Publishing Editor at Covers.com
Chris Vasile • Publishing Editor
Dec 15, 2024 • 08:41 ET • 4 min read
Travis Kelce Kansas City Chiefs NFL
Photo By - Imagn Images.

We're now into Week 15 of the NFL season, which means we are getting down to the nitty gritty of teams playing for playoff seeding... and some playing to secure a better draft pick. 

Join me as I break down my NFL picks against the spread for Week 15, including both Monday Night Football matchups. 

Week 15 picks against the spread

Matchup Pick
Rams Rams vs 49ers 49ers Rams (+2.5)
Bengals Bengals  vs Titans Titans Bengals (-5)
Chiefs Chiefs vs Browns Browns Chiefs (-4)
Ravens Ravens vs Giants Giants Giants (+15)
Cowboys Cowboys vs Panthers Panthers Cowboys (+2.5)
Jets Jets vs Jaguars Jaguars Jaguars (+3.5)
Commanders Commanders vs Saints Saints Commanders (-7)
Dolphins Dolphins vs Texans Texans Dolphins (+3)
Steelers Steelers vs Eagles Eagles Steelers (+5)
Bills Bills vs Lions Lions Lions (-1.5)
Colts Colts vs Broncos Broncos Broncos (-4)
Patriots Patriots vs  Cardinals Cardinals Cardinals (-5.5)
Buccaneers Buccaneers vs Chargers Chargers Buccaneers (+3)
Packers Packers vs Seahawks Seahawks Packers (-3)
Bears Bears vs Vikings Vikings Vikings (-7)
Falcons Falcons vs Raiders Raiders Raiders (+4.5)

Lines courtesy of bet365 as of 12-10

Expert Week 15 ATS picks

Rams vs 49ers
Rams Rams +2.5

At the moment, the Los Angeles Rams are the better and more complete team in this contest. Am I worried about a letdown after a high-scoring win vs. the Buffalo Bills? Yes, but I don't think the Niners are good enough to take advantage of it. Give me the points here with the divisional dog. 

Bengals vs Titans
Bengals Bengals -5

The Tennesee Titans just lost 10-6 to the Jacksonville Jaguars. What do you think the result will be when they have to deal with the best QB-WR combo in the league? Joe Burrow and Ja'Marr Chase will go off (again) and the Bengals win this one going away. 

Read our full Bengals vs. Titans predictions.

Chiefs vs Browns
Chiefs Chiefs -4

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This is the week. 

Read our full Chiefs vs. Browns predictions.

Ravens vs Giants
Giants Giants +15

Too many points. Just on principle alone, I'm taking the Giants. The Ravens have bigger and more important things to worry about than blowing out an also-ran. Ravens win by 10. 

Read our full Ravens vs. Giants predictions.

Cowboys vs Panthers
Cowboys Cowboys +2.5

The Cowboys showed some guts on MNF and I do believe Cooper Rush is starting to grow with the offense. This is a winnable game for the Cowboys, and the Panthers would be best served losing for a better draft position. 

Read our full Cowboys vs. Panthers predictions.

Jets vs Jaguars
Jaguars Jaguars +3.5

I'm only picking this game because I have to. With that said, give me Mac Jones over the corpse of Aaron Rodgers. The Jags look somewhat competent with him under center, and the Jets are just playing out the string. 

Read our full Jets vs. Jaguars predictions.

Commanders vs Saints
Commanders Commanders -7

The Saints are starting Spencer Rattler under center in this game, while the Washington Commanders are coming off their bye. The Commanders have made their hay by beating bad teams, and the Saints are just that. 

Read our full Commanders vs. Saints predictions.

Dolphins vs Texans
Dolphins Dolphins +3

Whether you want to believe it or not, the Dolphins are still somewhat alive in the wild card race. That'll be enough motivation to play well and beat an inconsistent Texans team. 

Read our full Dolphins vs. Texans predictions.

Steelers vs Eagles
Steelers Steelers +5

This is going to be a really good game, but I'll take the points here with the better defense. This will be the best defense the Eagles have played in a very long time, and I see this game being won by four points either way. 

Read our full Steelers vs. Eagles predictions.

Bills vs Lions
Lions Lions -1.5

If last week was a bad spot for the Bills, what is this week? An even worse one if you ask me. The Lions are well rounded and should have no issue shredding the Bills defense. 

Read our full Bills vs. Lions predictions.


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Colts vs Broncos
Broncos Broncos -4

I'm done backing the Colts, and you should be too. This team is awful and should have lost their last game to the Patriots, which would have made it five losses in six, not two wins in their last three. 

Read our full Colts vs. Broncos predictions.

Patriots vs Cardinals
Cardinals Cardinals -5.5

The Cardinals are good at home, and they beat up bad football teams. The Patriots are a bad football team, and I see the Cardinals putting up 30+. 

Read our full Patriots vs. Cardinals predictions.

Buccaneers vs Chargers
Buccaneers Buccaneers +3

The Bucs are playing some good football right now, and more importantly, they are healthy. The Chargers are banged up and may not have enough juice left after giving the Chiefs their best shot on SNF. 

Read our full Buccaneers vs. Chargers predictions.

Packers vs Seahawks
Packers Packers -3

Two of the Seahawks' last three wins came against the Cardinals  — a team whose number they just have. The Packers are a good team, and I believe they'll win this one by at least four points. 

Read our full Packers vs. Seahawks predictions.

Bears vs Vikings
Vikings Vikings -7

Nobody wants to bet on the Bears here, so chances are they cover. However, I'll take my chances, so give me the Vikings -7. 

Falcons vs Raiders
Raiders Raiders +4.5

Kirk Cousins? No thanks. Give me Desmond Ridder (oh god) in a revenge game against his former team. 

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Chris Vasile Covers.com
Publishing Editor

Chris Vasile has been in the betting industry for well over a decade honing his craft as a writer, editor and handicapper. A journalism graduate from Conestoga College in Kitchener, Ontario, Chris has contributed betting and non-betting content for online publications such as ProSportsDaily and The Hockey Writers, in addition to Covers. With a keen interest in soccer, Chris has been featured on Covers' 'Before You Bet' and runs his own YouTube channel — Game Day Wagers.

When it comes to daily sports betting, his sportsbook of choice is bet365 for the plethora of markets and great UX. Chris' top sports betting advice is to stick to what you know. Being a jack of all trades and master of none is a quick way to bust the bankroll. Find one or two sports you can devote your time to and trust the process.

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