Panthers vs Red Wings Prediction, Picks & Odds for Tonight’s NHL Game

The Red Wings may not have the playoffs in their immediate future, but they are the healthier team in this matchup as the Panthers remain without Aleksander Barkov and Matthew Tkachuk. Detroit takes this one.

Ryan Gilbert - Betting Analyst at Covers.com
Ryan Gilbert • Betting Analyst
Apr 5, 2025 • 12:21 ET • 4 min read
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This article contains predictions for an old game!

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The Florida Panthers conclude their four-game road trip with a matchup against the Detroit Red Wings tonight at Little Caesars Arena.

My Panthers vs. Red Wings picks are targeting Detroit as slight home underdogs in the best NHL picks on Sunday, April 6.

Panthers vs Red Wings prediction

My best bet: Red Wings moneyline (+100 at DraftKings)

My analysis
The Florida Panthers have stayed afloat despite some injuries in recent weeks, but it’s beginning to catch up with them. The recent addition of Brad Marchand helped replace Matthew Tkachuk on the wing, but a Selke Trophy favorite in Aleksander Barkov is harder to replace.

This will be the third straight game that Barkov has missed due to an upper-body injury and the Panthers have been outscored 6-2 in the previous two, including a 3-0 loss in Ottawa on Saturday afternoon. That was the Panthers' fourth straight loss after they won three of their previous four games — but all three of those victories came in overtime.

The Panthers are a respectable 7-5 on the second half of back-to-backs this season, but most of those weren’t with Vitek Vanecek in net. Florida is just 1-3 in Vanecek’s starts, and the netminder has allowed 12 goals in four games.

It’s ultimately too little too late for the Detroit Red Wings, but they’ve earned points in three straight games with wins over the Bruins and Hurricanes. They’re 20-16-3 at home this season, while the Panthers are 20-17-2 as the visitors.

The Red Wings have the rest advantage, are at home, and are healthier. Take them as the home dogs this evening as Florida nurses its wounds.

Panthers vs Red Wings same-game parlay (SGP)

Red Wings moneyline

Under 5.5

Seth Jones Over 1.5 shots on goal

The Panthers haven’t scored much recently, with two or fewer goals in five straight contests. The Red Wings should hold them to just a few goals, and it’s not as if Detroit has an explosive offense either.

Florida added defenseman Seth Jones at the deadline and he’s been a welcome addition for the Panthers. He has 34 shots on goal in 15 games with 2+ SOG in all but two of those contests.

Learn how to bet a same-game parlay with these helpful tips and strategies.

Panthers vs Red Wings odds

Panthers vs Red Wings live odds

Panthers vs Red Wings opening odds

  • Puck line: Florida -1.5 (+184) | Detroit +1.5 (-230)
  • Moneyline: Florida -130 | Detroit +108
  • Over/Under: Over 5.5 (-128) | Under 5.5 (+104)

Panthers vs Red Wings trend

The Florida Panthers have hit the Game Total Under in 57 of their last 105 games (+5.65 Units / 5% ROI). Find more NHL betting trends for Panthers vs. Red Wings.

How to watch Panthers vs Red Wings

Location Little Caesars Arena, Detroit, MI
Date Sunday, 4-6-2025
Puck drop 5:30 p.m. ET
TV TNT

Panthers vs Red Wings latest injuries

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Ryan Gilbert - Covers
Betting Analyst

Ryan Gilbert brings the passion and pain of being a Philadelphia sports fan. After graduating from Monmouth University with a finance degree, he now uses his statistical background to find inefficiencies in betting markets. With past stops at NHL.com, NBC Sports, and currently at Covers, Ryan's hot picks blend well with the cold ice of a hockey rink.

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