2025 March Madness Predictions & Picks: Get Our Best Bets for Every Single Game

With 67 games on the slate, we're betting on March Madness in a big way! We're making expert bracket picks on every game in the Round of 64 up to the Final Four and the title game, and you can expect a best bet and analysis for every game in the 2025 NCAA Men's Basketball Tournament.

With so many March Madness odds available, we'll have something for everyone! You can also check out our free college basketball picks collection for more great picks.

March Madness predictions & picks

As the odds roll in we'll post our picks right here on this page. Read our analysis, then use our college basketball odds comparison tool to ensure you get the best March Madness odds and Final Four odds.

March Madness champion prediction

• Auburn: +300
• Duke: +400
• Houston: +900
• Florida: +900
• Alabama: +1000
• Tennessee: +1800
• Iowa State: +1600
• Kentucky: +3500
• Texas Tech: +3500
• UConn: +5500

Odds courtesy of bet365 on 2-18.

Forged in the fires of the ultra-competitive SEC, the Tigers are great on both ends of the floor. Auburn has talent to spare, size and speed, and a great head coach in Bruce Pearl. The Tigers were the unanimous No. 1 overall seed in the bracket “sneak peak” and then went into Alabama and beat the second-best team in the nation this past weekend.
Pick: Auburn Tigers (+330)

Final Four prediction

• Auburn: -150
• Duke: -115
• Alabama: +165
• Houston: +165
• Florida: +180
• Tennessee: +340
• Iowa State: +390
• Texas A&M: +600
• Texas Tech: +700
• St. John's: +750

Odds courtesy of FanDuel on 2-18.

The Wildcats brought their brand of basketball to the Big 12 and have more than held their own. Arizona is 5-2 versus ranked opponents and boasts one of the best defenses in the country, rated No. 10 in adjusted defensive efficiency at KenPom – the tell-tale Final Four metric. The one thing that does worry me is the Wildcats’ inconsistent perimeter play and whether they can dig themselves out of a hole without solid 3-point shooting.
Final Four best bet: Arizona Wildcats (+900)

No. 1 Overall Seed prediction

• Auburn: -20000
• Duke: -9000
• Alabama: -250
• Florida: -150
• Houston: -120
• Tennessee: +200
• Iowa State: +3000
• Texas A&M: +3000
• Texas Tech: +3000
• Purdue: +5000

Odds courtesy of FanDuel on 2-18.

Houston had earned a No. 2 seed, according to the look-ahead bracket put out this past weekend. The Cougars then went out and beat a very good Arizona team on the road. Houston has a few more chances to boost its resume with matchups against TTU, Kansas and Iowa State. The Cougars could also slip past a team like Alabama, which has an incredibly tough home stretch. If the Tide tumble, UH could earn one of those four No. 1 spots.
Pick: Houston Cougars (-120)

2025 March Madness schedule

Where can I make my March Madness picks?

With March Madness being one of the most popular betting events of the year, every betting site will offer March Madness odds. But the best sites are safe and secure, offer a wide range of banking options, and give you a ton of markets for each game for your March Madness bets. Check out the best March Madness betting sites in your region and check out our free NCAAB Picks page for the best March Madness bets.

Best Bonuses

Along with our best betting sites, check out the best bonuses for the NCAA tournament.

Our process

Our analysts have spent countless hours following the 2024-25 college basketball season and are ready for the Big Dance. They start by looking at the game odds and then dive deep into the NCAAB matchups, looking for value and delivering well-thought-out March Madness bets and March Madness predictions. To learn more making picks on college basketball games, read our guide on how to bet on March Madness.

March Madness picks FAQs

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