The Arizona Cardinals and Detroit Lions are each looking for their second wins of 2024 when they face off at State Farm Stadium.
Arizona piled up 41 points on the Rams last week, and the offensive onslaught was spearheaded by the breakout performance of Marvin Harrison Jr.
Find out why my Lions vs. Cardinals predictions and NFL picks expect an encore performance on Sunday, September 22.
Lions vs Cardinals prediction
My best bet
Marvin Harrison Jr. Over 63.5 receiving yards (-115 at BetMGM)
My analysis
After recording just one catch for four yards on three targets in his Week 1 debut, Marvin Harrison Jr. broke out in a big way last week. He led the Arizona Cardinals with eight targets, catching four of them for 130 yards and two touchdowns.
The rookie wide receiver showed off his explosive play ability while bringing in two touchdowns on the Cardinals’ first two drives against the Rams. The first score was a 23-yard catch before Kyler Murray and Harrison connected on a 60-yard touchdown to go up 14-0.
Arizona spread the ball around a bit more after that and fell into a run-heavy attack given the large lead, but Harrison made a statement. Murray once again has a top wide receiver who can make big plays, and the Cards rookie is going to show that off any chance he gets.
Meanwhile, the Detroit Lions have already been victimized twice by top wide receivers this season. Rams wideout Cooper Kupp hauled in 14 passes for 110 yards in Week 1, and then Bucs' WR Chris Godwin recorded 117 yards last Sunday.
Harrison isn’t nearly as established as Kupp or Godwin, but he’s shown that he can reach this Over 63.5 yards number on just a play or two. Look for him to continue to grow his connection with Murray against the Rams.
Lions vs Cardinals same-game parlay
Marvin Harrison Jr. Over 62.5 receiving yards
Marvin Harrison Jr. anytime touchdown
Cardinals +3
The market isn’t respecting Harrison nearly enough. Sure, it was only one game, but the Ohio State star has the pedigree and matchup to blow past this 62.5-yard mark with at least one score against the Lions.
If Harrison does that, the Cardinals should remain in the game against a Detroit team that has yet to put away anyone this season.
Learn how to bet a same-game parlay with these helpful tips and strategies.
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Lions vs Cardinals odds
Lions vs Cardinals live odds
Lions vs Cardinals opening odds
- Spread: Detroit -3.5 | Arizona +3.5
- Moneyline: Detroit -190 | Arizona +155
- Over/Under: Over 51.5 | Under 51.5
Odds courtesy of BetMGM
Lions vs Cardinals spread and Over/Under analysis
- This line hasn’t moved too much since opening at -3.5. It’s been bet down to -3 at BetMGM, with Cardinals +3 slightly juiced to -115.
- The total also hasn’t moved much. It was briefly bet up to a flat 52.0, but is back down to 51.5 as of Saturday afternoon.
Lions vs Cardinals betting trend to know
Arizona has hit the game total Over in seven of its last nine games at home (+4.80 Units / 48% ROI). Find more NFL betting trends for Lions vs. Cardinals.
Lions vs Cardinals game info
| Location: | State Farm Stadium, Glendale, AZ |
| Date: | Sunday, 9-22, 2024 |
| Kickoff: | 4:25 p.m. ET |
| TV: | FOX |
Lions vs Cardinals latest injuries
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