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MLB Picks

Get free expert and computer MLB picks for every game on Sept. 22, 2026.

New Computer Picks powered by Odds Shark

Predicted Score

NYM logo
NYM
NYM

4.31 @ 4.42

TEX
TEX logo
TEX

Mets vs Rangers · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

NYM logo
NYM
NYM

4.31

+112

o8.0 -112

+1.5 -190

TEX logo
TEX
TEX

4.42

-121

u8.5 -112

-1.5 +165

Arizona @ Colorado
Matchup Stats

Predicted Score

AZ logo
AZ
AZ

6.09 @ 5.06

COL
COL logo
COL

Diamondbacks vs Rockies · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

AZ logo
AZ
AZ

6.09

-180

o10.5 -130

-1.5 -118

COL logo
COL
COL

5.06

+158

u11.0 -115

+1.5 +107

Top Projection Kyle Freeland o2.5 Strikeouts Thrown (-125)
o2.5-125
Houston @ Seattle
Matchup Stats

Predicted Score

HOU logo
HOU
HOU

3.89 @ 4.34

SEA
SEA logo
SEA

Astros vs Mariners · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

HOU logo
HOU
HOU

3.89

+120

o7.0 -120

+3.5 -700

SEA logo
SEA
SEA

4.34

-130

u8.5 -190

-3.5 +400

Top Projection Yordan Alvarez o1.5 Total Bases (+125)
o1.5+135
LA Angels @ Athletics
Matchup Stats

Predicted Score

LAA logo
LAA
LAA

5.43 @ 5.16

ATH
ATH logo
ATH

Angels vs Athletics · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

LAA logo
LAA
LAA

5.43

-107

o9.0 -143

+1.5 -225

ATH logo
ATH
ATH

5.16

-105

u9.5 -115

-1.5 +180

Top Projection Mike Trout o0.5 Total RBIs (+155)
o0.5+155
Minnesota @ San Francisco
Matchup Stats

Predicted Score

MIN logo
MIN
MIN

4.39 @ 3.40

SF
SF logo
SF

Twins vs Giants · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

MIN logo
MIN
MIN

4.39

-130

o7.0 -120

-1.5 +135

SF logo
SF
SF

3.40

+115

u7.5 -124

+1.5 -152

Top Projection Luke Keaschall o0.5 Total RBIs (+265)
o0.5+265
San Diego @ LA Dodgers
Matchup Stats

Predicted Score

SD logo
SD
SD

4.62 @ 5.16

LAD
LAD logo
LAD

Padres vs Dodgers · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

SD logo
SD
SD

4.62

+110

o8.0 -130

+1.5 -185

LAD logo
LAD
LAD

5.16

-125

u9.5 -200

-1.5 +163

Top Projection Will Smith o0.5 Total RBIs (+180)
o0.5+191
Washington @ Detroit
Matchup Stats

Predicted Score

WAS logo
WAS
WAS

3.59 @ 3.75

DET
DET logo
DET

Nationals vs Tigers · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

WAS logo
WAS
WAS

3.59

+160

o8.0 -102

+1.5 -140

DET logo
DET
DET

3.75

-180

u8.5 -142

-1.5 +122

Toronto @ Baltimore
Matchup Stats

Predicted Score

TOR logo
TOR
TOR

4.13 @ 4.33

BAL
BAL logo
BAL

Blue Jays vs Orioles · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

TOR logo
TOR
TOR

4.13

+105

o7.5 +105

+1.5 -225

BAL logo
BAL
BAL

4.33

-120

u7.5 -125

-1.5 +175

Minnesota @ San Francisco
Matchup Stats

Predicted Score

MIN logo
MIN
MIN

4.44 @ 3.22

SF
SF logo
SF

Twins vs Giants · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

MIN logo
MIN
MIN

4.44

--

--

--

SF logo
SF
SF

3.22

--

--

--

Milwaukee @ Philadelphia
Matchup Stats

Predicted Score

MIL logo
MIL
MIL

4.10 @ 3.98

PHI
PHI logo
PHI

Brewers vs Phillies · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

MIL logo
MIL
MIL

4.10

-136

o7.5 -102

-1.5 +135

PHI logo
PHI
PHI

3.98

+120

u7.5 -113

+1.5 -150

St. Louis @ Pittsburgh
Matchup Stats

Predicted Score

STL logo
STL
STL

4.30 @ 4.17

PIT
PIT logo
PIT

Cardinals vs Pirates · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

STL logo
STL
STL

4.30

--

--

--

PIT logo
PIT
PIT

4.17

--

--

--

Tampa Bay @ NY Yankees
Matchup Stats

Predicted Score

TB logo
TB
TB

3.76 @ 4.14

NYY
NYY logo
NYY

Rays vs Yankees · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

TB logo
TB
TB

3.76

+120

o7.0 -108

+1.5 -180

NYY logo
NYY
NYY

4.14

-139

u7.5 -137

-1.5 +165

Cleveland @ Boston
Matchup Stats

Predicted Score

CLE logo
CLE
CLE

3.81 @ 3.78

BOS
BOS logo
BOS

Guardians vs Red Sox · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

CLE logo
CLE
CLE

3.81

+120

o7.0 -118

+1.5 -190

BOS logo
BOS
BOS

3.78

-130

u7.5 -120

-1.5 +170

Cincinnati @ Atlanta
Matchup Stats

Predicted Score

CIN logo
CIN
CIN

3.86 @ 4.85

ATL
ATL logo
ATL

Reds vs Braves · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

CIN logo
CIN
CIN

3.86

+210

o7.0 -120

+1.5 -106

ATL logo
ATL
ATL

4.85

-245

u7.5 -120

-1.5 -110

Chi. White Sox @ Kansas City
Matchup Stats

Predicted Score

CHW logo
CHW
CHW

4.79 @ 4.89

KC
KC logo
KC

White Sox vs Royals · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

CHW logo
CHW
CHW

4.79

-112

o8.5 -107

-1.5 +150

KC logo
KC
KC

4.89

-102

u8.5 +100

+1.5 -173

Miami @ Chi. Cubs
Matchup Stats

Predicted Score

MIA logo
MIA
MIA

3.79 @ 4.63

CHC
CHC logo
CHC

Marlins vs Cubs · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

MIA logo
MIA
MIA

3.79

+150

o6.5 -139

+1.5 -150

CHC logo
CHC
CHC

4.63

-175

u7.0 -110

-1.5 +130

New York Mets image thumbnail NYM @ Texas Rangers image thumbnail TEX Tue, Sep 22 • 8:05 PM ET
Hits+Runs+RBIs
Jake Burger logo Jake Burger o1.5 Hits+Runs+RBIs (-105)
Best Odds
Pick made: 8 hours ago
Colby Marchio logo
Colby Marchio
Contributor

Jake Burger finds himself in a feast spot against Mets southpaw Sean Manaea, who has posted a near-17% barrel rate across his last five starts. Burger, meanwhile, has been torching left-handers, generating a 60% hard-hit rate and 35% barrel rate against the last 60 he has faced, along with a .731 SLG and .462 ISO. Manaea has also struggled to limit hard contact from right-handed hitters, allowing a 50% hard-hit rate and 13.6% barrel rate over his last 30. With Burger crushing southpaws and Manaea allowing plenty of hard contact, the Rangers slugger has a strong chance to leave the yard.

Walks Allowed
MacKenzie Gore logo MacKenzie Gore o1.5 Walks Allowed (-143)
Best Odds
Pick made: 8 hours ago
Colby Marchio logo
Colby Marchio
Contributor

MacKenzie Gore has struggled to find the zone recently, making his walks prop worth a look against the Mets. The Rangers left-hander owns a near 17% walk rate over his last five starts and has allowed at least three walks in five straight outings. New York has also been drawing walks at a strong clip against left-handed pitching, with seven hitters posting at least a 10% walk rate over their last 60 at-bats against southpaws. Gore could be on a short leash because of his command issues, but that also creates a path for this prop to cash early. I’m willing to play it up to -145.

View 15 Picks
Arizona Diamondbacks image thumbnail AZ @ Colorado Rockies image thumbnail COL Tue, Sep 22 • 8:40 PM ET
Earned Runs Allowed
Kyle Freeland logo Kyle Freeland o2.5 Earned Runs Allowed (-151)
Best Odds
Pick made: 9 hours ago
Colby Marchio logo
Colby Marchio
Contributor

Kyle Freeland has struggled at home this season, allowing 3.5 runs per outing while carrying the worst pitcher rating on Batters-Box’s current-season dataset. Now, he faces an Arizona Diamondbacks lineup featuring six elite-rated hitters and one with a strong rating. Arizona also owns the highest-rated lineup on today’s slate and enters this matchup swinging a hot bat, posting a 115 wRC+, .775 OPS and .341 wOBA over its last 12 games. With teams averaging roughly three runs through the first five innings and Colorado allowing well over three at home, the over 2.5 first-five runs stands out as the preferred number.

Total RBIs
Hunter Goodman logo
Hunter Goodman o0.5 Total RBIs (+135)
Projection 0.76
Best Odds
Pick made: a minute ago
EV Model Rating
Star rating: 4 out of 5
The leading projection system (THE BAT X) ranks Hunter Goodman as the majors's 12th-best home run hitter.. Hunter Goodman is projected to hit 4th on the lineup card today.. The #1 stadium in the majors for boosting offensive stats, per the leading projection system (THE BAT), is Coors Field.. Built 5197 feet above sea level, Coors Field has the highest altitude among all major league stadiums, which often leads to better offense.. In terms of temperature and humidity, the weather forecast calls for for the 3rd-most favorable hitting conditions of all games today.
View 11 Picks
Houston Astros image thumbnail HOU @ Seattle Mariners image thumbnail SEA Tue, Sep 22 • 9:40 PM ET
Total Home Runs
Yordan Alvarez logo Yordan Alvarez o0.5 Total Home Runs (+257)
Best Odds
Pick made: 6 hours ago
Colby Marchio logo
Colby Marchio
Contributor

We can finally trust the big fella once again, as Yordan Alvarez draws Seattle Mariners right-hander Logan Gilbert. The Houston Astros slugger owns a .559 SLG, .265 ISO, 57%+ hard-hit rate and 14.3% barrel rate over his last 10 games. Alvarez also enters Tuesday with an elite rating on Batters-Box and covers 100% of Gilbert’s pitch mix. Among 63 elite ratings this season, Alvarez has gone yard 22.22% of the time. Meanwhile, Gilbert’s last 30 left-handed hitters have posted a 52%+ hard-hit rate, 10.5% barrel rate, .460 xBA and .669 xSLG. Take this up to 30%.

Total Home Runs
Cal Raleigh logo Cal Raleigh o0.5 Total Home Runs (+300)
Best Odds
Pick made: 8 hours ago
Todd Cordell logo
Todd Cordell
Betting Analyst

Cal Raleigh is back and better than ever. Okay, maybe not ever – but he’s back!

Raleigh has hammered the fastball-sweeper combination over the last 25 games, posting a ridiculous .478 ISO and 35.7% barrel rate.

Raleigh only has seven career at-bats against Cristian Javier but hit safely in three of them, with one leaving the park.

View 14 Picks
Los Angeles Angels image thumbnail LAA @ Athletics Athletics image thumbnail ATH Tue, Sep 22 • 9:40 PM ET
Total Bases
Shea Langeliers logo
Shea Langeliers o1.5 Total Bases (-105)
Projection 2.28
Best Odds
Pick made: a minute ago
EV Model Rating
Star rating: 4 out of 5
The leading projection system (THE BAT X) projects Shea Langeliers in the 96th percentile when assessing his home run ability.. Shea Langeliers is projected to bat 2nd in the batting order in this matchup.. Sutter Health Park profiles as the #1 ballpark in the majors for righty home runs, per the leading projection system (THE BAT).. In the league, Sutter Health Park has the 4th-lowest average fence height.. Hot weather is strongly correlated with more offense (and fewer strikeouts), and the weather report forecasts the hottest weather on the slate today at 83°.
Total Bases
Oswald Peraza logo
Oswald Peraza o1.5 Total Bases (+185)
Projection 1.44
Best Odds
Pick made: a minute ago
EV Model Rating
Star rating: 3 out of 5
Sutter Health Park profiles as the #1 ballpark in the majors for righty home runs, per the leading projection system (THE BAT).. In the league, Sutter Health Park has the 4th-lowest average fence height.. Hot weather is strongly correlated with more offense (and fewer strikeouts), and the weather report forecasts the hottest weather on the slate today at 83°.. Hitting from the opposite that Brady Basso throws from, Oswald Peraza will have an edge today.. Oswald Peraza's ability to hit the ball at a base hit-optimizing launch angle (between -4° and 26°) has improved from last season to this one, going from 38.4% to 44.2%.
View 10 Picks
Minnesota Twins image thumbnail MIN @ San Francisco Giants image thumbnail SF Tue, Sep 22 • 9:45 PM ET
Total Home Runs
Drew Gilbert logo Drew Gilbert o0.5 Total Home Runs (+770)
Best Odds
Pick made: 9 hours ago
Quinn Allen logo
Quinn Allen
Betting Analyst

Play up to 20%. Drew Gilbert's recent power profile makes him an intriguing longshot. He's homered twice in five games while producing a .500 ISO, 60% hard-hit rate, and 20% barrel rate lately. Bradley has also been more vulnerable to home runs on the road, giving Gilbert a legitimate path to another bomb.

Total
Minnesota Twins image thumbnail San Francisco Giants image thumbnail o7.5 (-101)
Best Odds
Pick made: 9 hours ago
Quinn Allen logo
Quinn Allen
Betting Analyst

Play up to 55%. The bullpen matchup creates plenty of late scoring potential. San Francisco's relief corps has posted a 6.73 FIP with 2.45 HR/9 allowed over the last week, while Minnesota's pen hasn't exactly been dominant either. At only 7.5, one rough relief inning could quickly push this Over.

View 12 Picks
San Diego Padres image thumbnail SD @ Los Angeles Dodgers image thumbnail LAD Tue, Sep 22 • 10:10 PM ET
Total Home Runs
Jackson Merrill logo Jackson Merrill o0.5 Total Home Runs (+465)
Best Odds
Pick made: 6 hours ago
Colby Marchio logo
Colby Marchio
Contributor

San Diego Padres young buck Jackson Merrill is my favorite home run look in this matchup against Los Angeles Dodgers right-hander Roki Sasaki. Sasaki has gone back to his struggling ways, with the last 60 lefties he has faced owning a .417 xBA, .524 xSLG and .363 xwOBA. Meanwhile, Merrill has been crushing the ball over his last 10 games, maintaining a 67.7% hard-hit rate with a .628 SLG and .233 ISO. Sasaki has also posted a 5.02 ERA and 5.48 xERA over his last three starts while allowing nearly 46% hard contact. I’m backing Merrill to go yard.

Total Home Runs
Fernando Tatis Jr. logo Fernando Tatis Jr. o0.5 Total Home Runs (+373)
Best Odds
Pick made: 12 hours ago
JD Yonke logo
JD Yonke
Betting Analyst

Fernando Tatis Jr. has been scoring hot at the dish, leaving the yard five times in his last nine games. Dodger Stadium's 124 Park Factor for home runs means that there's an increased chance of Tatis continuing his fine form by popping a long ball.

 

View 15 Picks
Toronto Blue Jays image thumbnail TOR @ Baltimore Orioles image thumbnail BAL Wed, Sep 23 • 1:35 PM ET
Total Home Runs
George Springer logo George Springer o0.5 Total Home Runs (+850)
Pick made: 9 hours ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

What's wrong with a little double-dip on Springer tonight? Not only does he have strong numbers against Bassitt (2 HR, .631 xSLG), but six of his 15 homers this year have come off breaking balls - and we all know the veteran righty loves to throw the kitchen sink at hitters. If someone is going yard tonight, Springer is the most likely candidate, and at +850, we can't turn down that price.

Total
Toronto Blue Jays image thumbnail Baltimore Orioles image thumbnail o7.5 (+100)
Best Odds
Pick made: 9 hours ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

I'd price this closer to -110, so we're going to take advantage of this value. The Blue Jays see a familiar face on the bump in Chris Bassitt tonight, and while he's been fine over his last two starts, his 4.96 xERA suggests Toronto should be able to get to him. I'm expecting the Blue Jays to manufacture runs, with Bassitt posting a career-high xBA (.279) and career-low K rate (16.4%) this season. On the other side is Max Scherzer, who Baltimore just tagged for six earned runs 11 days ago. No matter how you slice it, tonight looks like we'll see some offensive fireworks. 

View 4 Picks

What Is An MLB Computer Pick?

MLB picks are bet suggestions based on our computer's assessment of the game. Tons of betting data goes into a computer pick, including pitching matchups, injury reports, analytics, and even recent betting trends.

How To Use MLB Computer Picks

You can use the tables above to help with your bets during the MLB season. The first section includes free, computer-generated picks for daily Major League Baseball games. Baseball bettors can choose to follow the computer, fade the computer, or simply use our computer picks as one element of their betting strategy.

This page also tees up access to deeper betting trends. For example, if a club's run line is favored, you can check their ATS trends, potentially opening up some quality underdog bets.

If you're ready to get started with MLB betting, visit our dedicated page highlighting the best MLB betting sites.

Moneyline

This is the most common and easiest wager for a bettor to make when it comes to MLB picks. Basically, to win an MLB moneyline pick, you just have to choose which team will win the game.

It's simple: if you bet the White Sox moneyline over the Red Sox and Chicago wins, you win your bet.

Run line

The run line is another name for a point spread that you may be more familiar with in NBA and NFL betting. A point spread varies in the NFL and NBA from as little as 0.5 points up to double-digit spreads. A baseball run line is almost always a 1.5-point spread.

The favorite will be -1.5 while the underdog will be +1.5. At the end of the game, if you take away 1.5 runs from the favorite or add 1.5 runs to the underdog and they end up winning the game, you win your MLB pick against the spread.

Totals (Over/Under)

Another common wager is to bet on the total in baseball, which is a bet on the total runs scored in the baseball game. You are simply choosing whether the final score will be Over or Under that total. Betting the Over/Under on a matchup is a great way to get started in MLB score predictions.

Free Computer Picks by Odds Shark

More MLB Picks & Betting Tools

NRFI/YRFI MLB Picks

A new and emerging MLB betting market is the NRFI/YRFI bet. These are quick-hitters in which you make a wager on the O/U total of the first inning, typically set at 0.5 runs. Thus, the bet is coined as No Run First Inning or Yes Run First Inning. No need to wait a couple of hours to cash a bet when it could be done in 20 minutes or less.

First Five Innings MLB Picks

The above options, moneyline, run line, and Over/Under, can also be placed on the first five innings of a game rather than the full game. Many experienced bettors will use this approach because, typically, this will take bullpens out of the equation and make your job researching the game easier. After all, you can just focus on the starting pitchers.

MLB Picks And Parlays

If you want to combine multiple games into one mega wager, you may consider making a parlay bet. A parlay is when you pick two or more MLB games on one single betting ticket, which will increase the payout of your bet.

But it also comes with more risk, as each of those MLB picks must hit for your ticket to pay out. Our parlay calculator is a great tool to find out what your potential payout would be.

If you're looking for more MLB picks content, check out our consensus picks and prop bets pages to get your fix. While you're at it, head over to our MLB promos page to get the best bang for your buck.

MLB Player Props

Player props are a great way to hone in on an individual matchup for a game. These types of wagers will be individualized for a player: Will Shohei Ohtani hit a home run? Will Gerrit Cole get seven strikeouts? Will Paul Skenes allow two earned runs?

You simply choose whether this outcome will happen or not. Keeping up to date on daily pitching matchups and batters on a hot streak can give you a huge boost when placing player prop bets.

MLB Futures Picks

Lastly, prior to the season and even throughout the season, you can place futures bets on all the long-term awards and outcomes. You can lock in an MLB pick on who will win their division, which squad will win the World Series, or even who will win the Rookie of the Year, MVP, or Cy Young.

MLB Free Picks FAQs

When do we release our MLB picks?

Covers’ MLB picks release on game day. Some significant matchups like playoff games release in the days leading up to the game.

What kinds of MLB picks do we make?

Covers provides free MLB picks covering many markets, including run lines, totals, moneylines, player props, and more.