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MLB Picks

Get free expert and computer MLB picks for every game on Sept. 22, 2026.

New Computer Picks powered by Odds Shark

Predicted Score

WAS logo
WAS
WAS

3.75 @ 4.29

DET
DET logo
DET

Nationals vs Tigers · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

WAS logo
WAS
WAS

3.75

+130

o8.0 -115

+1.5 -160

DET logo
DET
DET

4.29

-140

u8.5 -117

-1.5 +146

Milwaukee @ Philadelphia
Matchup Stats

Predicted Score

MIL logo
MIL
MIL

3.82 @ 4.22

PHI
PHI logo
PHI

Brewers vs Phillies · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

MIL logo
MIL
MIL

3.82

+120

o7.0 -120

+1.5 -182

PHI logo
PHI
PHI

4.22

-135

u7.5 -125

-1.5 +162

St. Louis @ Pittsburgh
Matchup Stats

Predicted Score

STL logo
STL
STL

3.86 @ 4.13

PIT
PIT logo
PIT

Cardinals vs Pirates · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

STL logo
STL
STL

3.86

+145

o7.0 -115

+1.5 -154

PIT logo
PIT
PIT

4.13

-164

u7.5 -125

-1.5 +140

Top Projection Jordan Walker o0.5 Total RBIs (+231)
o0.5+231
Cleveland @ Boston
Matchup Stats

Predicted Score

CLE logo
CLE
CLE

3.61 @ 3.83

BOS
BOS logo
BOS

Guardians vs Red Sox · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

CLE logo
CLE
CLE

3.61

+110

o6.5 -110

+1.5 -200

BOS logo
BOS
BOS

3.83

-125

u6.5 +100

-1.5 +173

Top Projection Wilyer Abreu o0.5 Total RBIs (+215)
o0.5+232
Tampa Bay @ NY Yankees
Matchup Stats

Predicted Score

TB logo
TB
TB

2.99 @ 3.90

NYY
NYY logo
NYY

Rays vs Yankees · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

TB logo
TB
TB

2.99

+116

o6.0 -110

+1.5 -200

NYY logo
NYY
NYY

3.90

-130

u6.5 -115

-1.5 +173

Top Projection Jonathan Aranda o0.5 Total RBIs (+275)
o0.5+290
Cincinnati @ Atlanta
Matchup Stats

Predicted Score

CIN logo
CIN
CIN

4.82 @ 5.21

ATL
ATL logo
ATL

Reds vs Braves · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

CIN logo
CIN
CIN

4.82

+160

o9.0 -115

+2.5 -225

ATL logo
ATL
ATL

5.21

-184

u9.5 -120

-2.5 +175

Top Projection Matt McLain o1.5 Total Bases (+260)
o1.5+260
Chi. White Sox @ Kansas City
Matchup Stats

Predicted Score

CHW logo
CHW
CHW

4.37 @ 4.30

KC
KC logo
KC

White Sox vs Royals · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

CHW logo
CHW
CHW

4.37

-117

o7.5 -120

-1.5 +145

KC logo
KC
KC

4.30

+105

u8.0 -115

+1.5 -164

Top Projection Bobby Witt Jr. o1.5 Total Bases (+117)
o1.5+117
Miami @ Chi. Cubs
Matchup Stats

Predicted Score

MIA logo
MIA
MIA

3.08 @ 3.65

CHC
CHC logo
CHC

Marlins vs Cubs · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

MIA logo
MIA
MIA

3.08

+174

o6.5 -115

+2.5 -225

CHC logo
CHC
CHC

3.65

-200

u7.0 -130

-2.5 +175

Top Projection Otto Lopez o0.5 Total RBIs (+300)
o0.5+319
NY Mets @ Texas
Matchup Stats

Predicted Score

NYM logo
NYM
NYM

4.28 @ 4.40

TEX
TEX logo
TEX

Mets vs Rangers · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

NYM logo
NYM
NYM

4.28

+110

o7.5 -121

+1.5 -190

TEX logo
TEX
TEX

4.40

-125

u8.5 -128

-1.5 +165

Top Projection MacKenzie Gore o4.5 Strikeouts Thrown (+117)
o4.5+117
Arizona @ Colorado
Matchup Stats

Predicted Score

AZ logo
AZ
AZ

6.14 @ 4.94

COL
COL logo
COL

Diamondbacks vs Rockies · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

AZ logo
AZ
AZ

6.14

-193

o10.5 -130

-1.5 -122

COL logo
COL
COL

4.94

+166

u11.0 -113

+1.5 +105

Top Projection Kyle Freeland o2.5 Strikeouts Thrown (-125)
o2.5-122
Houston @ Seattle
Matchup Stats

Predicted Score

HOU logo
HOU
HOU

4.01 @ 4.39

SEA
SEA logo
SEA

Astros vs Mariners · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

HOU logo
HOU
HOU

4.01

+120

o7.0 -120

+1.5 -179

SEA logo
SEA
SEA

4.39

-130

u7.5 -120

-1.5 +155

Top Projection Yordan Alvarez o1.5 Total Bases (+125)
o1.5+130
LA Angels @ Athletics
Matchup Stats

Predicted Score

LAA logo
LAA
LAA

5.44 @ 5.10

ATH
ATH logo
ATH

Angels vs Athletics · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

LAA logo
LAA
LAA

5.44

-107

o9.0 -139

+1.5 -225

ATH logo
ATH
ATH

5.10

-105

u9.5 -115

-1.5 +180

Top Projection Jonah Heim o0.5 Total RBIs (+190)
o0.5+190
Minnesota @ San Francisco
Matchup Stats

Predicted Score

MIN logo
MIN
MIN

4.43 @ 3.32

SF
SF logo
SF

Twins vs Giants · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

MIN logo
MIN
MIN

4.43

-130

o7.5 +100

-1.5 +135

SF logo
SF
SF

3.32

+115

u9.5 -260

+1.5 -152

Top Projection Luke Keaschall o0.5 Total RBIs (+239)
o0.5+239
San Diego @ LA Dodgers
Matchup Stats

Predicted Score

SD logo
SD
SD

4.55 @ 5.01

LAD
LAD logo
LAD

Padres vs Dodgers · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

SD logo
SD
SD

4.55

+112

o8.0 -134

+1.5 -185

LAD logo
LAD
LAD

5.01

-124

u9.5 -186

-1.5 +165

Top Projection Teoscar Hernandez o0.5 Total RBIs (+195)
o0.5+210
Washington @ Detroit
Matchup Stats
Toronto @ Baltimore
Matchup Stats

Predicted Score

TOR logo
TOR
TOR

4.13 @ 4.33

BAL
BAL logo
BAL

Blue Jays vs Orioles · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

TOR logo
TOR
TOR

4.13

+102

o7.5 +105

+1.5 -225

BAL logo
BAL
BAL

4.33

-120

u7.5 -125

-1.5 +165

Minnesota @ San Francisco
Matchup Stats

Predicted Score

MIN logo
MIN
MIN

4.54 @ 3.29

SF
SF logo
SF

Twins vs Giants · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

MIN logo
MIN
MIN

4.54

--

--

--

SF logo
SF
SF

3.29

--

--

--

Milwaukee @ Philadelphia
Matchup Stats

Predicted Score

MIL logo
MIL
MIL

4.09 @ 3.96

PHI
PHI logo
PHI

Brewers vs Phillies · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

MIL logo
MIL
MIL

4.09

-136

o7.5 -105

-1.5 +130

PHI logo
PHI
PHI

3.96

+120

u7.5 -114

+1.5 -156

St. Louis @ Pittsburgh
Matchup Stats

Predicted Score

STL logo
STL
STL

4.23 @ 4.11

PIT
PIT logo
PIT

Cardinals vs Pirates · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

STL logo
STL
STL

4.23

--

--

--

PIT logo
PIT
PIT

4.11

--

--

--

Tampa Bay @ NY Yankees
Matchup Stats
Cleveland @ Boston
Matchup Stats

Predicted Score

CLE logo
CLE
CLE

3.88 @ 3.87

BOS
BOS logo
BOS

Guardians vs Red Sox · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

CLE logo
CLE
CLE

3.88

+120

o7.0 -120

+1.5 -185

BOS logo
BOS
BOS

3.87

-134

u7.5 -120

-1.5 +168

Cincinnati @ Atlanta
Matchup Stats
Chi. White Sox @ Kansas City
Matchup Stats

Predicted Score

CHW logo
CHW
CHW

4.79 @ 4.88

KC
KC logo
KC

White Sox vs Royals · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

CHW logo
CHW
CHW

4.79

--

--

--

KC logo
KC
KC

4.88

--

--

--

Miami @ Chi. Cubs
Matchup Stats

Predicted Score

MIA logo
MIA
MIA

2.81 @ 3.79

CHC
CHC logo
CHC

Marlins vs Cubs · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

MIA logo
MIA
MIA

2.81

--

--

--

CHC logo
CHC
CHC

3.79

--

--

--

Washington Nationals image thumbnail WAS @ Detroit Tigers image thumbnail DET Tue, Sep 22 • 6:40 PM ET
Total RBIs
Spencer Torkelson logo
Spencer Torkelson o0.5 Total RBIs (+187)
Projection 0.51
Best Odds
Pick made: a minute ago
EV Model Rating
Star rating: 3 out of 5
The leading projection system (THE BAT X) projects Spencer Torkelson in the 93rd percentile as it relates to his home run ability.. Comerica Park has the 3rd-shortest fence height (on average) in Major League Baseball.. Comerica Park sits at the 9th-highest altitude in the majors. High elevation often leads to better offense.. Batting from the opposite that Riley Cornelio throws from, Spencer Torkelson will have an edge in today's matchup.. Among all the teams in action today, the 3rd-weakest infield defense belongs to the Washington Nationals.
Total RBIs
CJ Abrams logo
CJ Abrams o0.5 Total RBIs (+185)
Projection 0.51
Best Odds
Pick made: 10 minutes ago
EV Model Rating
Star rating: 3 out of 5
When it comes to his overall offensive skill, CJ Abrams ranks in the 84th percentile according to the leading projections (THE BAT X).. CJ Abrams is projected to bat 4th on the lineup card today.. Comerica Park has the 3rd-shortest fence height (on average) in Major League Baseball.. Comerica Park sits at the 9th-highest altitude in the majors. High elevation often leads to better offense.. Batting from the opposite that Drew Anderson throws from, CJ Abrams will have the upper hand in today's matchup.
View 4 Picks
Milwaukee Brewers image thumbnail MIL @ Philadelphia Phillies image thumbnail PHI Tue, Sep 22 • 6:40 PM ET
Total Home Runs
Bryce Harper logo Bryce Harper o0.5 Total Home Runs (+589)
Best Odds
Pick made: 3 hours ago
Neil Parker logo
Neil Parker
Betting Analyst

Harper has a single homer across his past 22 games despite a solid 25-for-85 run at the dish, and he also paces Philly with an elite .298 ISO against righties. This is also a favorable matchup with Milwaukee starter Dustin May struggling to the tune of a 6.91 xERA while allowing a healthy 36.7% hard-hit rate to leeft-handed hitters across his past six starts.

Total
Milwaukee Brewers image thumbnail Philadelphia Phillies image thumbnail o7.5 (+110)
Best Odds
Pick made: 3 hours ago
Neil Parker logo
Neil Parker
Betting Analyst

This Over 7.5 is in play to 55% because while Philly starter Zack Wheeler has been exceptional (2.63 xERA and 3.30 xFIP across his past four starts), the Brewers also send a well-rounded lineup to the plate. Milwaukee is second in the majors in wOBA against righties for the season, and the Brew Crew also rank second in overall wOBA and seventh in xwOBA over the past 30 days. So, with Brewers righty Dustin May sporting a 6.91 xERA and 4.42 xFIP across his last six outings, I expect the Philadelphia offense to do the heavy lifting while Milwaukee chips in enough runs to send this total Over the number tonight. 

View 13 Picks
St. Louis Cardinals image thumbnail STL @ Pittsburgh Pirates image thumbnail PIT Tue, Sep 22 • 6:40 PM ET
Total RBIs
Brandon Lowe logo
Brandon Lowe o0.5 Total RBIs (+193)
Projection 0.53
Best Odds
Pick made: a minute ago
EV Model Rating
Star rating: 3 out of 5
The leading projection system (THE BAT X) projects Brandon Lowe in the 90th percentile when it comes to his home run talent.. Brandon Lowe is projected to hit 2nd in the batting order today.. The leading projection system (THE BAT) profiles PNC Park as the 3rd-best park in baseball for LHB BABIP.. Batting from the opposite that Andre Pallante throws from, Brandon Lowe will have an edge today.. Brandon Lowe has a ton of pop (90th percentile) if he makes contact, but that's usually a big "IF" (27.1% K%). Today, however, opposing pitcher Andre Pallante is a pitch-to-contact type (25th percentile K%) — great news for Lowe.
Total RBIs
Jordan Walker logo
Jordan Walker o0.5 Total RBIs (+235)
Projection 0.54
Best Odds
Pick made: 2 minutes ago
EV Model Rating
Star rating: 4 out of 5
The leading projection system (THE BAT X) projects Jordan Walker in the 91st percentile as it relates to his overall offensive skill.. Jordan Walker is penciled in 4th in the batting order in today's game.. PNC Park projects as the #3 ballpark in Major League Baseball for righty BABIP, according to the leading projection system (THE BAT).. In the past week, Jordan Walker's Barrel% has experienced a surge, jumping from his seasonal rate of 13.3% up to 33.3%.. Jordan Walker has seen a sizeable increase in his exit velocity lately; just compare his 99.1-mph average in the past two weeks' worth of games to his seasonal 92.7-mph figure.
View 10 Picks
Cleveland Guardians image thumbnail CLE @ Boston Red Sox image thumbnail BOS Tue, Sep 22 • 6:45 PM ET
Total Home Runs
Jo Adell logo Jo Adell o0.5 Total Home Runs (+465)
Best Odds
Pick made: 2 hours ago
Colby Marchio logo
Colby Marchio
Contributor

Jo Adell draws a favorable matchup against Red Sox southpaw Payton Tolle, who has struggled against right-handed hitters of late despite his strong overall results. Over the last 60 right-handed bats Boston has faced, hitters are making 50% hard contact with a 28.9% ground-ball rate, while posting a .349 xBA and .633 xSLG. Adell has been crushing left-handed pitching all season and has taken things up another notch over his last 60 at-bats. During that span, he owns a .712 SLG, .347 ISO and 17.1% barrel rate while consistently keeping the ball elevated. Take this down to 20%.

Total Home Runs
Wilyer Abreu logo Wilyer Abreu o0.5 Total Home Runs (+675)
Best Odds
Pick made: 5 hours ago
Todd Cordell logo
Todd Cordell
Betting Analyst

Wilyer Abreu's ISO sits at .190 facing southpaws but spikes to .267 when isolating the fastball-sinker combination that Parker Messick relies on so heavily.

His strikeout rate sits at just 13.2% against those two pitches, which is below his barrel rate of 14.5%. It’s always a good sign when you’re making elite contact more frequently than punching out.

 

 

View 14 Picks
Tampa Bay Rays image thumbnail TB @ New York Yankees image thumbnail NYY Tue, Sep 22 • 7:05 PM ET
Total Bases
Victor Mesa Jr. logo
Victor Mesa Jr. o1.5 Total Bases (+225)
Projection 1.25
Best Odds
Pick made: 2 minutes ago
EV Model Rating
Star rating: 3 out of 5
Yankee Stadium has the 8th-lowest fences among all major league stadiums.. Over the past week, Victor Mesa Jr.'s 33.3% rate of hitting balls at a HR-optimizing launch angle (between 23° and 34°) shows big improvement over his seasonal rate of 19.5%.. Utilizing Statcast data, Victor Mesa Jr. ranks in the 85th percentile for hitting ability per the leading projection system (THE BAT X)'s version of Expected wOBA (xwOBA) since the start of last season at .340.. Victor Mesa Jr.'s 21.8° launch angle (a reliable standard to evaluate a batter's ability to lift the ball for power) is among the steepest in MLB: 93rd percentile.. In notching a .347 wOBA (a leading indicator of offensive ability) this year, Victor Mesa Jr. finds himself in the 86th percentile.
Total RBIs
Cody Bellinger logo
Cody Bellinger o0.5 Total RBIs (+240)
Projection 0.44
Best Odds
Pick made: 2 minutes ago
EV Model Rating
Star rating: 3 out of 5
The leading projection system (THE BAT X) projects Cody Bellinger in the 86th percentile when assessing his batting average skill.. Cody Bellinger is projected to bat 2nd in the lineup today.. Yankee Stadium has the 8th-lowest fences among all major league stadiums.. Cody Bellinger will have the benefit of the platoon advantage against Drew Rasmussen in today's game.. Cody Bellinger will probably have the upper hand against every reliever throughout the game, since the bullpen of the Tampa Bay Rays only has 1 same-handed RP.
View 5 Picks
Cincinnati Reds image thumbnail CIN @ Atlanta Braves image thumbnail ATL Tue, Sep 22 • 7:15 PM ET
Total Home Runs
Ronald Acuna Jr. logo Ronald Acuna Jr. o0.5 Total Home Runs (+319)
Best Odds
Pick made: 36 minutes ago
Jason Ence logo
Jason Ence
Betting Analyst

Acuna will have the early advantage on Williamson, and likely will get two ABs against the lefty before facing the poor Reds' bullpen. Acuna is also mashing in September, with a 25.9% HR/FB rate, 41.7% hard%, and a .356 ISO—ranked eighth among all hitters this month.

Total
Cincinnati Reds image thumbnail Atlanta Braves image thumbnail o9.5 (+103)
Best Odds
Pick made: 38 minutes ago
Jason Ence logo
Jason Ence
Betting Analyst

Playable to 49%, I am expecting a high-scoring affair.

The Braves turn to JR Ritchie, whose erratic command has led to a walk rate in the fourth percentile this year, and a 7.15 FIP since the break.

Cincy's pen the past two weeks ranks 29th in HR/9 (2.31), 28th in FIP (5.75), and 25th in hard% (36.1%).

View 13 Picks
Chicago White Sox image thumbnail CHW @ Kansas City Royals image thumbnail KC Tue, Sep 22 • 7:40 PM ET
Total Hits
Randal Grichuk logo
Randal Grichuk u0.5 Total Hits (+170)
Projection 0.74
Best Odds
Pick made: a minute ago
EV Model Rating
Star rating: 4 out of 5
This year, Randal Grichuk has been pulled from the game early in 58% of his appearances when starting against left-handed starter.. The wind projects to be blowing in from CF at 9.2-mph in this game, the 5th-best of the day for mound aces.. In today's matchup, Randal Grichuk is at a disadvantage facing the league's deepest LF fences given that he hits his flyballs to the pull field at a 34.1% rate (77th percentile).. Out of every team playing today, the strongest infield defense belongs to the Kansas City Royals.. Playing on the road generally diminishes batter metrics in all categories due to the lack of home field advantage, which figures to be the case for Randal Grichuk in today's game.
Total RBIs
Bobby Witt Jr. logo
Bobby Witt Jr. o0.5 Total RBIs (+190)
Projection 0.6
Best Odds
Pick made: a minute ago
EV Model Rating
Star rating: 4 out of 5
As it relates to his batting average talent, Bobby Witt Jr. is projected as the 2nd-best batter in Major League Baseball by the leading projection system (THE BAT X).. Bobby Witt Jr. is projected to bat 2nd on the lineup card in today's game.. Kauffman Stadium grades out as the #7 field in baseball for run-scoring, via the leading projection system (THE BAT).. Kauffman Stadium sits at the 4th-highest altitude in MLB. High elevation usually leads (as a rule of thumb) to better offense.. High humidity has a small but significant correlation with more offense (and fewer Ks), and the weather report calls for the 3rd-highest humidity of all games today at 75%.
View 10 Picks
Miami Marlins image thumbnail MIA @ Chicago Cubs image thumbnail CHC Tue, Sep 22 • 7:40 PM ET
Total Bases
Dansby Swanson logo
Dansby Swanson u1.5 Total Bases (-210)
Projection 0.7
Best Odds
Pick made: a minute ago
EV Model Rating
Star rating: 4 out of 5
Dansby Swanson is penciled in 9th in the lineup in this game.. In the majors, the 7th-highest fence height (on average) are at Wrigley Field.. The weather forecast forecasts the 4th-best pitching conditions on the slate today, as it relates to temperature and humidity.. The wind projects to be blowing in from RF at 15-mph in this game, the best of the day for pitchers.. Janson Junk will receive the benefit of the platoon advantage against Dansby Swanson in today's game.
Total Bases
Ian Happ logo
Ian Happ u1.5 Total Bases (-235)
Projection 0.69
Best Odds
Pick made: a minute ago
EV Model Rating
Star rating: 3 out of 5
In the majors, the 7th-highest fence height (on average) are at Wrigley Field.. The weather forecast forecasts the 4th-best pitching conditions on the slate today, as it relates to temperature and humidity.. The wind projects to be blowing in from RF at 15-mph in this game, the best of the day for pitchers.. Today, Ian Happ is at a disadvantage facing the league's 5th-deepest RF fences given that he hits his flyballs to the pull field at a 36.7% rate (90th percentile).. Sporting a .221 batting average this year, Ian Happ has performed in the 15th percentile.
View 10 Picks
New York Mets image thumbnail NYM @ Texas Rangers image thumbnail TEX Tue, Sep 22 • 8:05 PM ET
Hits+Runs+RBIs
Jake Burger logo Jake Burger o1.5 Hits+Runs+RBIs (-105)
Best Odds
Pick made: 4 hours ago
Colby Marchio logo
Colby Marchio
Contributor

Jake Burger finds himself in a feast spot against Mets southpaw Sean Manaea, who has posted a near-17% barrel rate across his last five starts. Burger, meanwhile, has been torching left-handers, generating a 60% hard-hit rate and 35% barrel rate against the last 60 he has faced, along with a .731 SLG and .462 ISO. Manaea has also struggled to limit hard contact from right-handed hitters, allowing a 50% hard-hit rate and 13.6% barrel rate over his last 30. With Burger crushing southpaws and Manaea allowing plenty of hard contact, the Rangers slugger has a strong chance to leave the yard.

Walks Allowed
MacKenzie Gore logo MacKenzie Gore o1.5 Walks Allowed (-143)
Best Odds
Pick made: 4 hours ago
Colby Marchio logo
Colby Marchio
Contributor

MacKenzie Gore has struggled to find the zone recently, making his walks prop worth a look against the Mets. The Rangers left-hander owns a near 17% walk rate over his last five starts and has allowed at least three walks in five straight outings. New York has also been drawing walks at a strong clip against left-handed pitching, with seven hitters posting at least a 10% walk rate over their last 60 at-bats against southpaws. Gore could be on a short leash because of his command issues, but that also creates a path for this prop to cash early. I’m willing to play it up to -145.

View 15 Picks
Arizona Diamondbacks image thumbnail AZ @ Colorado Rockies image thumbnail COL Tue, Sep 22 • 8:40 PM ET
Earned Runs Allowed
Kyle Freeland logo Kyle Freeland o2.5 Earned Runs Allowed (-151)
Best Odds
Pick made: 4 hours ago
Colby Marchio logo
Colby Marchio
Contributor

Kyle Freeland has struggled at home this season, allowing 3.5 runs per outing while carrying the worst pitcher rating on Batters-Box’s current-season dataset. Now, he faces an Arizona Diamondbacks lineup featuring six elite-rated hitters and one with a strong rating. Arizona also owns the highest-rated lineup on today’s slate and enters this matchup swinging a hot bat, posting a 115 wRC+, .775 OPS and .341 wOBA over its last 12 games. With teams averaging roughly three runs through the first five innings and Colorado allowing well over three at home, the over 2.5 first-five runs stands out as the preferred number.

Total Bases
Corbin Carroll logo
Corbin Carroll o1.5 Total Bases (-125)
Projection 2.12
Best Odds
Pick made: a minute ago
EV Model Rating
Star rating: 3 out of 5
When it comes to his overall offensive talent, Corbin Carroll ranks in the 97th percentile according to the leading projections (THE BAT X).. Corbin Carroll is projected to hit 5th in the lineup today.. The #1 stadium in the majors for boosting offensive stats, per the leading projection system (THE BAT), is Coors Field.. Built 5197 feet above sea level, Coors Field has the highest altitude among all major league stadiums, which often leads to better offense.. In terms of temperature and humidity, the weather forecast calls for for the 3rd-most favorable hitting conditions of all games today.
View 11 Picks
Houston Astros image thumbnail HOU @ Seattle Mariners image thumbnail SEA Tue, Sep 22 • 9:40 PM ET
Total Home Runs
Yordan Alvarez logo Yordan Alvarez o0.5 Total Home Runs (+257)
Best Odds
Pick made: 2 hours ago
Colby Marchio logo
Colby Marchio
Contributor

We can finally trust the big fella once again, as Yordan Alvarez draws Seattle Mariners right-hander Logan Gilbert. The Houston Astros slugger owns a .559 SLG, .265 ISO, 57%+ hard-hit rate and 14.3% barrel rate over his last 10 games. Alvarez also enters Tuesday with an elite rating on Batters-Box and covers 100% of Gilbert’s pitch mix. Among 63 elite ratings this season, Alvarez has gone yard 22.22% of the time. Meanwhile, Gilbert’s last 30 left-handed hitters have posted a 52%+ hard-hit rate, 10.5% barrel rate, .460 xBA and .669 xSLG. Take this up to 30%.

Total Home Runs
Cal Raleigh logo Cal Raleigh o0.5 Total Home Runs (+300)
Best Odds
Pick made: 4 hours ago
Todd Cordell logo
Todd Cordell
Betting Analyst

Cal Raleigh is back and better than ever. Okay, maybe not ever – but he’s back!

Raleigh has hammered the fastball-sweeper combination over the last 25 games, posting a ridiculous .478 ISO and 35.7% barrel rate.

Raleigh only has seven career at-bats against Cristian Javier but hit safely in three of them, with one leaving the park.

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Los Angeles Angels image thumbnail LAA @ Athletics Athletics image thumbnail ATH Tue, Sep 22 • 9:40 PM ET
Total RBIs
Shea Langeliers logo
Shea Langeliers o0.5 Total RBIs (+130)
Projection 0.87
Best Odds
Pick made: 11 minutes ago
EV Model Rating
Star rating: 4 out of 5
The leading projection system (THE BAT X) projects Shea Langeliers in the 96th percentile when assessing his home run ability.. Shea Langeliers is projected to bat 3rd in the batting order in this matchup.. Sutter Health Park profiles as the #1 ballpark in the majors for righty home runs, per the leading projection system (THE BAT).. In the league, Sutter Health Park has the 4th-lowest average fence height.. Hot weather is strongly correlated with more offense (and fewer strikeouts), and the weather report forecasts the 2nd-hottest weather on the slate today at 81°.
Total Bases
Shea Langeliers logo
Shea Langeliers o1.5 Total Bases (-110)
Projection 2.23
Best Odds
Pick made: 36 minutes ago
EV Model Rating
Star rating: 4 out of 5
The leading projection system (THE BAT X) projects Shea Langeliers in the 96th percentile when assessing his home run ability.. Shea Langeliers is projected to bat 3rd in the batting order in this matchup.. Sutter Health Park profiles as the #1 ballpark in the majors for righty home runs, per the leading projection system (THE BAT).. In the league, Sutter Health Park has the 4th-lowest average fence height.. Hot weather is strongly correlated with more offense (and fewer strikeouts), and the weather report forecasts the 2nd-hottest weather on the slate today at 81°.
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Minnesota Twins image thumbnail MIN @ San Francisco Giants image thumbnail SF Tue, Sep 22 • 9:45 PM ET
Total Home Runs
Drew Gilbert logo Drew Gilbert o0.5 Total Home Runs (+770)
Best Odds
Pick made: 4 hours ago
Quinn Allen logo
Quinn Allen
Betting Analyst

Play up to 20%. Drew Gilbert's recent power profile makes him an intriguing longshot. He's homered twice in five games while producing a .500 ISO, 60% hard-hit rate, and 20% barrel rate lately. Bradley has also been more vulnerable to home runs on the road, giving Gilbert a legitimate path to another bomb.

Total
Minnesota Twins image thumbnail San Francisco Giants image thumbnail o7.5 (-101)
Best Odds
Pick made: 4 hours ago
Quinn Allen logo
Quinn Allen
Betting Analyst

Play up to 55%. The bullpen matchup creates plenty of late scoring potential. San Francisco's relief corps has posted a 6.73 FIP with 2.45 HR/9 allowed over the last week, while Minnesota's pen hasn't exactly been dominant either. At only 7.5, one rough relief inning could quickly push this Over.

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San Diego Padres image thumbnail SD @ Los Angeles Dodgers image thumbnail LAD Tue, Sep 22 • 10:10 PM ET
Total Home Runs
Jackson Merrill logo Jackson Merrill o0.5 Total Home Runs (+465)
Best Odds
Pick made: an hour ago
Colby Marchio logo
Colby Marchio
Contributor

San Diego Padres young buck Jackson Merrill is my favorite home run look in this matchup against Los Angeles Dodgers right-hander Roki Sasaki. Sasaki has gone back to his struggling ways, with the last 60 lefties he has faced owning a .417 xBA, .524 xSLG and .363 xwOBA. Meanwhile, Merrill has been crushing the ball over his last 10 games, maintaining a 67.7% hard-hit rate with a .628 SLG and .233 ISO. Sasaki has also posted a 5.02 ERA and 5.48 xERA over his last three starts while allowing nearly 46% hard contact. I’m backing Merrill to go yard.

Total Home Runs
Fernando Tatis Jr. logo Fernando Tatis Jr. o0.5 Total Home Runs (+373)
Best Odds
Pick made: 7 hours ago
JD Yonke logo
JD Yonke
Betting Analyst

Fernando Tatis Jr. has been scoring hot at the dish, leaving the yard five times in his last nine games. Dodger Stadium's 124 Park Factor for home runs means that there's an increased chance of Tatis continuing his fine form by popping a long ball.

 

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Toronto Blue Jays image thumbnail TOR @ Baltimore Orioles image thumbnail BAL Wed, Sep 23 • 1:35 PM ET
Total Home Runs
George Springer logo George Springer o0.5 Total Home Runs (+850)
Best Odds
Pick made: 4 hours ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

What's wrong with a little double-dip on Springer tonight? Not only does he have strong numbers against Bassitt (2 HR, .631 xSLG), but six of his 15 homers this year have come off breaking balls - and we all know the veteran righty loves to throw the kitchen sink at hitters. If someone is going yard tonight, Springer is the most likely candidate, and at +850, we can't turn down that price.

Total
Toronto Blue Jays image thumbnail Baltimore Orioles image thumbnail o7.5 (+100)
Best Odds
Pick made: 5 hours ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

I'd price this closer to -110, so we're going to take advantage of this value. The Blue Jays see a familiar face on the bump in Chris Bassitt tonight, and while he's been fine over his last two starts, his 4.96 xERA suggests Toronto should be able to get to him. I'm expecting the Blue Jays to manufacture runs, with Bassitt posting a career-high xBA (.279) and career-low K rate (16.4%) this season. On the other side is Max Scherzer, who Baltimore just tagged for six earned runs 11 days ago. No matter how you slice it, tonight looks like we'll see some offensive fireworks. 

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You can use the tables above to help with your bets during the MLB season. The first section includes free, computer-generated picks for daily Major League Baseball games. Baseball bettors can choose to follow the computer, fade the computer, or simply use our computer picks as one element of their betting strategy.

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The run line is another name for a point spread that you may be more familiar with in NBA and NFL betting. A point spread varies in the NFL and NBA from as little as 0.5 points up to double-digit spreads. A baseball run line is almost always a 1.5-point spread.

The favorite will be -1.5 while the underdog will be +1.5. At the end of the game, if you take away 1.5 runs from the favorite or add 1.5 runs to the underdog and they end up winning the game, you win your MLB pick against the spread.

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Another common wager is to bet on the total in baseball, which is a bet on the total runs scored in the baseball game. You are simply choosing whether the final score will be Over or Under that total. Betting the Over/Under on a matchup is a great way to get started in MLB score predictions.

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A new and emerging MLB betting market is the NRFI/YRFI bet. These are quick-hitters in which you make a wager on the O/U total of the first inning, typically set at 0.5 runs. Thus, the bet is coined as No Run First Inning or Yes Run First Inning. No need to wait a couple of hours to cash a bet when it could be done in 20 minutes or less.

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The above options, moneyline, run line, and Over/Under, can also be placed on the first five innings of a game rather than the full game. Many experienced bettors will use this approach because, typically, this will take bullpens out of the equation and make your job researching the game easier. After all, you can just focus on the starting pitchers.

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If you want to combine multiple games into one mega wager, you may consider making a parlay bet. A parlay is when you pick two or more MLB games on one single betting ticket, which will increase the payout of your bet.

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