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Best NFL Picks Today

Find the best NFL bets today - Sept. 17, 2026. Free expert and computer picks for every NFL game.

New Computer Picks powered by Odds Shark

Predicted Score

DET logo
DET
DET

26.70 @ 28.72

BUF
BUF logo
BUF

Lions vs Bills · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

DET logo
DET
DET

26.70

+5.5 -105

o54.5 -114

+210

BUF logo
BUF
BUF

28.72

-5.5 -105

u55.5 -125

-244

Philadelphia @ Tennessee
Matchup Stats

Predicted Score

PHI logo
PHI
PHI

23.91 @ 15.39

TEN
TEN logo
TEN

Eagles vs Titans · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

PHI logo
PHI
PHI

23.91

-6.5 -135

o39.5 -109

-310

TEN logo
TEN
TEN

15.39

+6.5 -111

u40.0 -115

+290

Top Projection Tony Pollard o44.5 Rushing Yards (+105)
o40.5-135
Pittsburgh @ New England
Matchup Stats

Predicted Score

PIT logo
PIT
PIT

18.96 @ 24.55

NE
NE logo
NE

Steelers vs Patriots · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

PIT logo
PIT
PIT

18.96

+5.5 -110

o41.5 -108

+200

NE logo
NE
NE

24.55

-5.5 -105

u41.5 -107

-218

Top Projection Aaron Rodgers Score a Touchdown (Yes: +2500)
+2500
Minnesota @ Chicago
Matchup Stats

Predicted Score

MIN logo
MIN
MIN

17.72 @ 24.37

CHI
CHI logo
CHI

Vikings vs Bears · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

MIN logo
MIN
MIN

17.72

+4.5 -110

o47.5 -115

+185

CHI logo
CHI
CHI

24.37

-4.5 -105

u48.5 -111

-198

Top Projection Carson Wentz o10.5 Rushing Yards (+115)
o8.5-110
Carolina @ Atlanta
Matchup Stats

Predicted Score

CAR logo
CAR
CAR

22.35 @ 22.99

ATL
ATL logo
ATL

Panthers vs Falcons · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

CAR logo
CAR
CAR

22.35

+0.0 -152

o43.5 -110

-140

ATL logo
ATL
ATL

22.99

+2.5 -102

u44.0 -110

+125

Top Projection Drake London o54.5 Receiving Yards (-115)
o54.5-115
Green Bay @ N.Y. Jets
Matchup Stats

Predicted Score

GB logo
GB
GB

25.01 @ 18.82

NYJ
NYJ logo
NYJ

Packers vs Jets · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

GB logo
GB
GB

25.01

-3.5 +100

o44.5 -105

-180

NYJ logo
NYJ
NYJ

18.82

+3.5 -106

u44.5 -105

+164

Top Projection Geno Smith o6.5 Rushing Yards (-115)
o6.5-115
New Orleans @ Baltimore
Matchup Stats

Predicted Score

NO logo
NO
NO

20.28 @ 26.24

BAL
BAL logo
BAL

Saints vs Ravens · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

NO logo
NO
NO

20.28

+8.5 -109

o45.5 -118

+333

BAL logo
BAL
BAL

26.24

-8.5 +100

u46.5 -107

-380

Top Projection Lamar Jackson u40.5 Rushing Yards (-115)
u42.5-118
Cincinnati @ Houston
Matchup Stats

Predicted Score

CIN logo
CIN
CIN

24.17 @ 24.85

HOU
HOU logo
HOU

Bengals vs Texans · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

CIN logo
CIN
CIN

24.17

+2.5 +100

o45.0 -110

+128

HOU logo
HOU
HOU

24.85

-2.5 -105

u46.5 -115

-134

Top Projection Ja'Marr Chase o74.5 Receiving Yards (-115)
o70.5-125
Cleveland @ Tampa Bay
Matchup Stats

Predicted Score

CLE logo
CLE
CLE

15.11 @ 22.78

TB
TB logo
TB

Browns vs Buccaneers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

CLE logo
CLE
CLE

15.11

+8.5 -109

o40.5 -122

+360

TB logo
TB
TB

22.78

-8.5 +100

u41.5 -110

-420

Jacksonville @ Denver
Matchup Stats

Predicted Score

JAC logo
JAC
JAC

21.07 @ 24.53

DEN
DEN logo
DEN

Jaguars vs Broncos · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

JAC logo
JAC
JAC

21.07

+3.5 -135

o45.0 -110

+130

DEN logo
DEN
DEN

24.53

-3.5 -115

u45.5 -109

-145

Top Projection Evan Engram o25.5 Receiving Yards (-105)
o23.5-114
Las Vegas @ L.A. Chargers
Matchup Stats

Predicted Score

LV logo
LV
LV

18.70 @ 25.43

LAC
LAC logo
LAC

Raiders vs Chargers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

LV logo
LV
LV

18.70

+6.5 -102

o43.5 -105

+250

LAC logo
LAC
LAC

25.43

-6.5 -110

u43.5 -107

-290

Seattle @ Arizona
Matchup Stats

Predicted Score

SEA logo
SEA
SEA

21.31 @ 20.95

ARI
ARI logo
ARI

Seahawks vs Cardinals · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

SEA logo
SEA
SEA

21.31

+0.0 -204

o40.5 -120

-198

ARI logo
ARI
ARI

20.95

+0.0 +155

u41.5 -115

+185

Top Projection Jacoby Brissett o10.5 Rushing Yards (+115)
o5.5-110
Miami @ San Francisco
Matchup Stats

Predicted Score

MIA logo
MIA
MIA

18.86 @ 26.91

SF
SF logo
SF

Dolphins vs 49ers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

MIA logo
MIA
MIA

18.86

+13.5 -106

o44.5 -115

+700

SF logo
SF
SF

26.91

-13.5 -105

u45.5 -110

-900

Top Projection Brock Purdy o15.5 Rushing Yards (+100)
o11.5-115
Washington @ Dallas
Matchup Stats

Predicted Score

WAS logo
WAS
WAS

24.38 @ 28.78

DAL
DAL logo
DAL

Commanders vs Cowboys · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

WAS logo
WAS
WAS

24.38

+4.5 -115

o50.5 -110

+175

DAL logo
DAL
DAL

28.78

-4.5 -104

u50.5 -108

-200

Top Projection Dak Prescott o10.5 Rushing Yards (+115)
o8.5-110
Indianapolis @ Kansas City
Matchup Stats

Predicted Score

IND logo
IND
IND

20.01 @ 23.92

KC
KC logo
KC

Colts vs Chiefs · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

IND logo
IND
IND

20.01

+7.5 -141

o46.0 -110

+265

KC logo
KC
KC

23.92

-7.5 +104

u47.0 -114

-290

Top Projection Daniel Jones o10.5 Rushing Yards (+115)
o8.5-111
N.Y. Giants @ L.A. Rams
Matchup Stats

Predicted Score

NYG logo
NYG
NYG

19.82 @ 28.90

LA
LA logo
LA

Giants vs Rams · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

NYG logo
NYG
NYG

19.82

+7.5 -115

o48.0 -110

+275

LA logo
LA
LA

28.90

-7.5 +100

u48.5 -110

-340

Top Projection Matthew Stafford Score a Touchdown (Yes: +2000)
+2400
Detroit Lions image thumbnail DET @ Buffalo Bills image thumbnail BUF Thu, Sep 17 • 8:15 PM ET
Spread
Detroit Lions image thumbnail DET +5.5 (-112)
Best Odds
Pick made: 2 hours ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

The line moving from +3.5 to +5.5 is just too much for me, so I'll bite on Detroit in what should be a shootout on Thursday Night Football. Dan Campbell knows how to get his guys ready for primetime, too - he's 13-3 SU and 3-0 on TNF in his career. If the Houston Texans can drop 31 points on this Bills defense, what will the Lions do? Let's bank on this high-octane offense to keep it close.

Receptions Made
DJ Moore logo DJ Moore o4.5 Receptions Made (+105)
Best Odds
Pick made: 19 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

Dalton Kincaid stole the receiving headlines in Week 1, but the new guy had a team-high eight targets and hauled in five for 100 yards and a score. He also led all Buffalo pass-catchers in target share (28.6%) and air-yard share (44%). Buffalo only ran the ball on 35% of its plays in Week 1, and things might be a little more pass-heavy with a healthy Kincaid and Moore on the scene now. This game projects to have the most plays in Week 2, and for DJ Moore to have 7.9 targets. This prop is on the move.

View 23 Picks
Philadelphia Eagles image thumbnail PHI @ Tennessee Titans image thumbnail TEN Sun, Sep 20 • 1:00 PM ET
Anytime Touchdown
Jalen Hurts logo Jalen Hurts Score a Touchdown (Yes: +150)
Best Odds
Pick made: 42 minutes ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

Eagles OC Sean Mannion was asked if we’re going to get more runs from Hurts after only 7 carries in Week 1. He told the media we would, stating, “It’s certainly something that really unlocks things for us.” Given that the Week 2 defense is Tennessee, I expect Hurts to have a big day on the ground and find the end zone, especially with the “Tush Push” at play. 

Anytime Touchdown
Saquon Barkley logo Saquon Barkley Score a Touchdown (Yes: -104)
Best Odds
Pick made: 3 hours ago
Neil Parker logo
Neil Parker
Betting Analyst

After being held out of the end zone in Week 1, I’m anticipating Barkley scoring against the Titans. Tennessee finished 28th in run defense DVOA and 24th in PFF run defense grade while allowing 142 rushing yards to backs in the season opener, and now they face an elite offensive line that ranked 10th in run block win rate last week. Of course, Barkley also handled 33.8% of the touches and 48.3% of the carries inside the red zone last year.

View 16 Picks
Pittsburgh Steelers image thumbnail PIT @ New England Patriots image thumbnail NE Sun, Sep 20 • 1:00 PM ET
Spread
Pittsburgh Steelers image thumbnail PIT +5.5 (-110)
Best Odds
Pick made: 4 minutes ago
Neil Parker logo
Neil Parker
Betting Analyst

With the Steelers sending out a capable, experienced and versatile defense, I’m happy to take the points in what I forecast to be a low-scoring game. Pittsburgh QB Aaron Rodgers finished with the seventh-highest PFF offense grade among quarterbacks and didn’t have a single turnover worthy play in Week 1, and the Steelers also finished the week ranked No. 1 in defensive DVOA while allowing the second-lowest EPA per play.

Anytime Touchdown
DK Metcalf logo DK Metcalf Score a Touchdown (Yes: +310)
Best Odds
Pick made: 15 minutes ago
Neil Parker logo
Neil Parker
Betting Analyst

This is a fair number for Metcalf to find the end zone. He paced the Steelers in targets with a 27% share in Week 1, and he also garnered a respectable 28.6% of red-zone touches in 2025. Additionally, the 6-foot-4 Metcalf has a notable size advantage over the New England secondary, and I expect McCarthy to create opportunities for his go-to receiver to avoid being blanketed by Patriots star shadow cornerback Christian Gonzalez.

View 17 Picks
Minnesota Vikings image thumbnail MIN @ Chicago Bears image thumbnail CHI Sun, Sep 20 • 1:00 PM ET
Anytime Touchdown
Caleb Williams logo Caleb Williams Score a Touchdown (Yes: +360)
Best Odds
Pick made: 23 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

After running 10 times for 65 yards and two scores last week, Caleb Williams' TD price hasn't seen a big correction after closing at 20% in Week 1. Williams should not be this long for a TD after a 59-point game and as the seventh-most probable Bear to score. Even in the two meetings last season against the Vikings, the Chicago quarterback ran 10 times for 84 yards and a score. The Vikings' all-out blitz defense only helps create big-gain rushing opportunities for opposing QBs, while the Packers also put up 419 yards of offense against Minnesota, which was a bottom-five mark last week. Williams likely won't take off 10 times again, but if this offense stays aggressive, his TD price could drop. That's a price I'm willing to pay this week at 25% or better.

Spread
Chicago Bears image thumbnail CHI -5.5 (-110)
Best Odds
Pick made: 3 days ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

While Wentz was serviceable, I see more than two points separating him and Murry in terms of value to the spread. That’s especially true if the Bears can break away on the scoreboard and force Wentz to carry the load. Minnesota’s defense is dangerous but gave up a ton of yards to the Packers. If we take the Cheeseheads’ fourth-quarter collapse out of the equation, the Vikes stop unit was 21st in EPA allowed per play in the first three quarters. Murray’s chances of clearing concussion protocols seems slim when you look at his reaction to the hit. Once he’s officially ruled out, this spread jumps to Bears -6 or higher. Give me Chicago below the key number now.

View 12 Picks
Carolina Panthers image thumbnail CAR @ Atlanta Falcons image thumbnail ATL Sun, Sep 20 • 1:00 PM ET
Anytime Touchdown
Chuba Hubbard logo Chuba Hubbard Score a Touchdown (Yes: +100)
Best Odds
Pick made: 3 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

The Falcons are a no-go with their QB play, and Chuba Hubbard is the man in this Carolina offense, which won't go up and down the field like they did against Chicago every week. Hubbard is a great play here at 55.6% or lower, or 1.8x. The RB1 took almost 80% of the RB snaps before the final drive, and Jonathan Brooks, coming back from multiple lengthy injuries, received just 12 offensive snaps. It was also Hubbard who got all four of the RB red-zone opportunities, which he turned into two scores at 2.2x. I thought about chasing the Jalen Coker TD, but Hubbard is a needed safe floor when you have a lengthy TD card. Carolina is going to dominate the TOP and run the ball all day.

Total
Carolina Panthers image thumbnail Atlanta Falcons image thumbnail o43.5 (-111)
Best Odds
Pick made: 3 days ago
Shawn Krest logo
Shawn Krest
Betting Analyst

Stay Over up to 45.5. The Panthers answered all questions about their offense in the opener, and the Carolina defense didn't show it was capable of stopping anyone. The Panthers have set scoring records for the preseason Hall of Fame Game and the NFL Week One opener. 

View 13 Picks
Green Bay Packers image thumbnail GB @ New York Jets image thumbnail NYJ Sun, Sep 20 • 1:00 PM ET
Anytime Touchdown
Braelon Allen logo Braelon Allen Score a Touchdown (Yes: +310)
Best Odds
Pick made: 5 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

This is still a +EV TD with a fair price of 3.5x (28.6%), and it's easy to see why. Braelon Allen saw double-digit carries last week against the Titans and played the majority of the snaps on third and fourth down with two or fewer yards to go. It was Breece Hall getting the red-zone carries, but there weren't any short TD opportunities, and Allen handled the majority of the third-down work. The Packers gave up TDs to both Minnesota backs last week and were one of the worst teams in the red zone, allowing a touchdown on all four Minnesota opportunities inside the 20. Their turnovers and penalties can only help New York keep a neutral game script.

Total
Green Bay Packers image thumbnail New York Jets image thumbnail u44.5 (-111)
Best Odds
Pick made: 2 days ago
Ed Scimia logo
Ed Scimia
Betting Analyst

The New York Jets averaged just 17.6 ppg last year and while Geno Smith is an upgrade at quarterback, I'm unconvinced that he's going to improve the situation all that much at age 35. Meanwhile, the Jets defense will get pressure on a one-dimensional Green Bay Packers offense that totaled just 66 yards on the ground against the Vikings. I'm backing the Under down to 42.5 points.

View 15 Picks
New Orleans Saints image thumbnail NO @ Baltimore Ravens image thumbnail BAL Sun, Sep 20 • 1:00 PM ET
Rushing Yards
Tyler Shough logo Tyler Shough o11.5 Rushing Yards (-110)
Best Odds
Pick made: an hour ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

Tyler Shough ran four times for only eight yards in a thrilling loss to the Lions in Week 1. The Saints QB faces a Ravens defense that blitzed the snot out of Colts QB Daniel Jones in Week 1. He’ll be forced to out of pocket and put on the run. As a rookie, Shough amassed 10 rushing yards or more in six of his 10 starts with some big gains, like 55 yards versus the blitz-happy Bucs. Projections all sit well above this lower total, ranging from 15 to 21+ rushing yards. His Week 1 total was 18.5 yards O/U and his last five rushing yard total in 2025 were between 16.5 and 20.5 O/U. This 11.5 O/U total seems like an overcorrection to that low Week 1 outing.

Anytime Touchdown
Durham Smythe logo Durham Smythe Score a Touchdown (Yes: +850)
Best Odds
Pick made: 4 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

I got this at 10.5% (9.5x) and would play this to 7x (14.2%). Durham Smythe might have even more opportunities than last week with the injuries to the Baltimore pass-catchers. Smythe played 62% of the snaps in Week 1, had one RZ target, and might see his routes increase with Ja'Kobi Lane out and Zay Flowers banged up. The Ravens ran heavy sets at a 53% rate last week against the Colts, and with so much uncertainty around the WR rotation, especially with the possibility of Devontez Walker coming back, I'll take a half-unit long shot on a guy playing a decent amount of snaps in an offense that's humming out of the gates.

View 13 Picks
Cincinnati Bengals image thumbnail CIN @ Houston Texans image thumbnail HOU Sun, Sep 20 • 1:00 PM ET
Anytime Touchdown
Chase Brown logo Chase Brown Score a Touchdown (Yes: +114)
Best Odds
Pick made: 23 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

This might be the best price we get for Chase Brown all season. He should not be 50% or lower in any game, and this price is giving the Texans too much credit after a similar top-tier offense just put up 36 points and 409 total yards in Houston last week. Chase Brown got six of the seven running back red-zone opportunities last week, including all three carries inside the five, where he cashed a -125 touchdown. He's scored seven TDs over his last four games dating back to last season, and I have him at a base probability of 55.6% against an average defense.

 

Spread
Houston Texans image thumbnail HOU -2.5 (-110)
Best Odds
Pick made: 3 days ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

The Bengals got four takeaways and still had to sweat out the Bucs in Week 1. Houston's defense bounces back and that offense is improved and always strong at home. The Texans were 9 for 18 on 3rd/4th down conversions and went 4/5 for TDs in the red zone. Cincy finished 2/5 in RZ and needed a defensive score and four FGM (two 50+ yarders) to get to 33 points, despite those extra possesions.

View 12 Picks
Cleveland Browns image thumbnail CLE @ Tampa Bay Buccaneers image thumbnail TB Sun, Sep 20 • 1:00 PM ET
Anytime Touchdown
Deshaun Watson logo Deshaun Watson Score a Touchdown (Yes: +600)
Best Odds
Pick made: 4 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

Sometimes people in the dumps need some support, and that's where I am with Deshaun Watson this week at a 7x TD price that should not be more than 5x. He had a very difficult Week 1 matchup against that Jaguars defense. Things should be a little easier against the Buccaneers, who allowed 5.6 yards per play and five red-zone opportunities to the Bengals. Watson ran six times last week for 38 yards, including twice in the red zone, and was one of only eight QBs who had multiple RZ rushes in Week 1. He's locked into the No. 1 role and will want to silence the Cleveland fans in Week 3 in the home opener with at least something positive this week. Just think of the bragging rights you'll get if you cash a 7x Watson TD when the world is rooting against him.

Receiving Yards
Harold Fannin Jr. logo
Harold Fannin Jr. o33.5 Receiving Yards (-115)
Projection 39.91 (Over)
Best Odds
Pick made: a minute ago
EV Model Rating
Star rating: 5 out of 5
At a -8.5-point disadvantage, the Browns are big underdogs in this game, implying much more of a focus on throwing than their typical game plan.. The Tampa Bay Buccaneers defense has conceded the 7th-most adjusted receiving yards per game in the NFL (58.0) to TEs since the start of last season.. Since the start of last season, the anemic Tampa Bay Buccaneers pass defense has conceded a whopping 78.6% Adjusted Completion Rate versus opposing tight ends: the 7th-largest rate in football.
View 11 Picks
Jacksonville Jaguars image thumbnail JAC @ Denver Broncos image thumbnail DEN Sun, Sep 20 • 4:05 PM ET
Anytime Touchdown
Bhayshul Tuten logo Bhayshul Tuten Score a Touchdown (Yes: +220)
Best Odds
Pick made: 2 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

It seems every offensive position for the Broncos is a crowded mess, and that Week 1 prime-time performance left a sour taste in my mouth. The Jaguars, however, looked as good as the Bills and Ravens. The Denver run defense knew Kenneth Walker was coming with a hobbled Patrick Mahomes and still got run over. That's where the 3.2x comes in for Bhayshul Tuten, and it's a price I'd take to 2.5x. The Jacksonville backfield was pretty split, and Tuten didn't play a huge amount at 48% of the snaps, but when he was on the field, he got the ball. He had 16 opportunities on 27 snaps, and the blowout might have muddied the actual rotation. Chris Rodriguez could poach some goal-line work, and his 4.1x price is also something to consider. I just think the Jacksonville running game and offense aren't getting enough credit against a Denver defense that did nothing and is on a short week.

Rushing Yards
Bo Nix logo
Bo Nix o17.5 Rushing Yards (-120)
Projection 22.38 (Over)
Best Odds
Pick made: 35 minutes ago
EV Model Rating
Star rating: 5 out of 5
Our trusted projections expect the Broncos to run the 4th-most offensive plays among all teams this week with 66.1 plays, given their underlying traits and game dynamics.. The Broncos have run the 8th-most plays in football since the start of last season, totaling a staggering 58.7 plays per game.. When it comes to the linebackers' role in stopping the run, Jacksonville's collection of LBs has been awful since the start of last season, projecting as the 10th-worst in football. in football.
View 11 Picks
Las Vegas Raiders image thumbnail LV @ Los Angeles Chargers image thumbnail LAC Sun, Sep 20 • 4:05 PM ET
Anytime Touchdown
Michael Mayer logo Michael Mayer Score a Touchdown (Yes: +270)
Best Odds
Pick made: 2 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

I got this at 3.7x and would play to 3.2x. The Raiders should be playing in a negative game script on Sunday, and Michael Mayer could be the most-targeted Raider in an indoor game against a Chargers team that is in a must-win spot in Week 2. Last week as the TE1, Mayer led the Silver and Black in target share at 24% and targets per route run at 30%. He had seven targets and caught six balls, with the Raiders playing with the lead from start to finish. He was also one of three pass-catchers to see a target in the red zone. He isn't running deep routes, but that's a good thing when his QB is Kirk Cousins. He could have a big-volume game if Las Vegas is forced to pass more than its 46% rate in Week 1.

Rushing Yards
Omarion Hampton logo
Omarion Hampton o64.5 Rushing Yards (-110)
Projection 79.19 (Over)
Best Odds
Pick made: 11 minutes ago
EV Model Rating
Star rating: 5 out of 5
This game's line implies an extreme rushing game script for the Chargers, who are a heavy favorite by 7 points.. The predictive model expects the Los Angeles Chargers as the 5th-most run-centric team among all teams this week with a 47.5% run rate, based on their underlying strategic approach and matchup dynamics.. The 7th-most plays in the NFL have been run by the Los Angeles Chargers since the start of last season (a colossal 59.5 per game on average).
View 10 Picks
Seattle Seahawks image thumbnail SEA @ Arizona Cardinals image thumbnail ARI Sun, Sep 20 • 4:25 PM ET
Anytime Touchdown
Jadarian Price logo Jadarian Price Score a Touchdown (Yes: +140)
Best Odds
Pick made: an hour ago
Josh Inglis logo
Josh Inglis
Betting Analyst

Let's not get carried away with Arizona's Week 1 win, and getting an RB1 against this team at 2.4x is a steal. Jadarian Price got his feet wet in the opener and was the preferred back on first and second down, with George Holani getting 92% of the third-down work. He'll have another week to plan with new QB Drew Lock, which could make this team more run-heavy than it was with Sam Darnold. The Seahawks only ran 48 plays last Wednesday, so Price's 10-carry, 52-yard game should have more volume in Week 2. The Seahawks had zero carries inside the 10-yard line, but George Holani took the only two red-zone carries. Here's hoping Mike Macdonald and Brian Fleury let Price eat a little more in the Price vs. Jeremiyah Love game.

Receiving Yards
Jadarian Price logo
Jadarian Price o8.5 Receiving Yards (-115)
Projection 12.16 (Over)
Best Odds
Pick made: 3 minutes ago
EV Model Rating
Star rating: 5 out of 5
The Seahawks will be starting backup QB Drew Lock this week, which typically means fewer pass attempts and more rushing.. The pass games of both teams (in terms of both volume and effectiveness) figure to benefit from the calm "weather" conditions (as in zero wind) inside this dome, while run volume may decline.
View 11 Picks
Miami Dolphins image thumbnail MIA @ San Francisco 49ers image thumbnail SF Sun, Sep 20 • 4:25 PM ET
Rushing Yards
Christian McCaffrey logo Christian McCaffrey o57.5 Rushing Yards (-115)
Best Odds
Pick made: 15 minutes ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

Christian McCaffrey can gash this Dolphins defense for big gains on the ground in Week 2. Miami was 24th in Run Defense DVOA in Week 1 and allowed 100+ yards to Raiders RB Ashton Jeanty. The Fins could be missing two starters on the defensive line and Run CMC has fresh legs with an extended break after thumping the Rams in Australia. He had only 10 carries in that one-side win due to cramping – giving way to rookie RB Kaelon Black - and even with game script calling for another 49ers blowout, projections sit north of 60+ yards with a ceiling of 68. My number comes out to 63 yards from McCaffrey on Sunday.

Anytime Touchdown
Demarcus Robinson logo Demarcus Robinson Score a Touchdown (Yes: +351)
Best Odds
Pick made: an hour ago
Josh Inglis logo
Josh Inglis
Betting Analyst

Everyone and their mom is likely looking to bet on Kaelon Black this weekend to score vs. the Dolphins, but I don't love his 3x price. I'd rather play him for last TD at 10.5x, but that seems pretty close to fair. The real value is with Demarcus Robinson, who played 91% of the snaps after rookie De'Zhaun Stribling exited. He's out long-term. The loss of Jake Tonges also opens some snaps for Robinson in a pass-catching group of oft-injured older players who might not respond well to the travel to Australia and back. Robinson is a buy to 3.8x and is the best-valued TD according to the Covers Anytime Touchdown Value Index, which hit its top-valued TD last week with Dallas Goedert.

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Washington Commanders image thumbnail WAS @ Dallas Cowboys image thumbnail DAL Sun, Sep 20 • 4:25 PM ET
Anytime Touchdown
Jake Ferguson logo Jake Ferguson Score a Touchdown (Yes: +265)
Best Odds
Pick made: an hour ago
Josh Inglis logo
Josh Inglis
Betting Analyst

This TD is popping on the projections at its 3.65x price, with a fair price of 3.2x. It's also the No. 5 TD on the Covers Anytime Touchdown Value Index (68). The Commanders just gave up a monster line to another TE last week in Dallas Goedert, who went for 4-77-2. His TD was the highest-value play on the TD Value Index last week. Ferguson saw just two targets on SNF but still played 75% of the snaps, which ranked behind only CeeDee Lamb and George Pickens. If Ferguson finds paydirt in Week 2, the Commanders are officially TE funnels.

Passing Touchdowns
Jayden Daniels logo Jayden Daniels o1.5 Passing Touchdowns (+155)
Best Odds
Pick made: an hour ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

To steal a line from Eminem, “MFers act like they forgot about Jay”. Jayden Daniels passed for two touchdowns against a much stronger Eagles secondary last week and faces a softer Dallas defense inside on the fast track at AT&T Stadium in Week 2. Daniels is being discounted after his injury-shortened 2025 but folks forget just how great a passer he is when healthy. Projections lean toward two TD throws and with such a tall total, game script says this is a shootout.

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Indianapolis Colts image thumbnail IND @ Kansas City Chiefs image thumbnail KC Sun, Sep 20 • 8:20 PM ET
Anytime Touchdown
Alec Pierce logo Alec Pierce Score a Touchdown (Yes: +350)
Best Odds
Pick made: an hour ago
Josh Inglis logo
Josh Inglis
Betting Analyst

Remember when we got Kenneth Walker at close to even money? Not anymore. The Chiefs players are hard to back at their current prices. However, the market is low on the Colts, who are giant dogs in this game despite the Chiefs playing on a short week. This Alec Pierce price is also well off fair, from 4.5x to a fair of 3.4x. Pierce exited early in Week 1 but came back and played close to 90% of the snaps in the second half. This is still a KC secondary that had plenty of turnover from the previous year, and although Bo Nix and the Broncos couldn't figure it out, there should be plenty of negative game script for Daniel Jones to keep chucking the ball. If Pierce plays average in this game, this price will never appear again.

Rushing Yards
Daniel Jones logo Daniel Jones o8.5 Rushing Yards (-108)
Best Odds
Pick made: 4 hours ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

Jones was under fire from the Baltimore defense in the opener. Despite all that pressure, Jones ran only one time for four yards. He’s a sneaky fast quarterback who broke away for at least 10 rushing yards in five of his 13 starts last year, including 16 yards on three carries versus Kansas City in Week 12. He was also playing hurt in most of those starts. On top of running away from the Chiefs pass rush on Sunday night, Jones often gets his number called on short yardage situations. His Week 1 rushing total was 10.5 O/U and his projections sat as high as 21 yards. After than lone carry versus Baltimore, this market is shrinking but forecasts still sit north of 10 rushing yards with a ceiling of 21 yards again. My number comes out to 18+ gains on the ground.

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New York Giants image thumbnail NYG @ Los Angeles Rams image thumbnail LA Mon, Sep 21 • 8:15 PM ET
Anytime Touchdown
Isaiah Likely logo Isaiah Likely Score a Touchdown (Yes: +266)
Best Odds
Pick made: 43 minutes ago
Josh Inglis logo
Josh Inglis
Betting Analyst

Isaiah Likely was the cash converter last week and was a huge part of the Giants' offense, keeping pace with Malik Nabers in terms of usage and volume. Despite that, his TD price has not moved, which I don't mind at all. I understand it's the Rams, but they are just getting back from Australia and looked awful defending the pass in Week 1. Likely had four targets in the red zone and finished with two TDs. No other TE or WR had more than three RZ catches in Week 1. Likely is the No. 2 in this passing game and is a green light for a TD buy at 3x or better right now.

Game Prop
Los Angeles Rams image thumbnail o27.5 Team Total (-120)
Best Odds
Pick made: 2 days ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

Sean McVay is an excellent game planner with added time he'll work out the kinks on this offense. Matthew Stafford couldn’t get going against the 49ers but faces a softer stop unit from the Giants. New York’s defense looked much better than it truly was in Week 1, due to the offense grinding out gains and chewing up TOP. The Cowboys offense only had two second half possessions and while it was limited in action, Dallas ranked out well in terms of advanced metrics like EPA per play DVOA. This is a fast track indoor at SoFi Stadium and it doesn’t seem likely that L.A.’s offense gets bottled up for a second straight game. 

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For every matchup in an NFL season, our NFL computer produces selections for a variety of different betting angles. Our computer picks are based on a proprietary algorithm that values each team in the current week to produce moneyline, spread, and point total selections.

The table above, below the game picks, tracks our NFL computer's results over the last 100 games, outlining the record and profit for selections, based on $100 unit size. We track the profit based on both opening and closing lines for every matchup.

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The easiest way to utilize our computer picks is to simply follow our selections for every matchup, what you'd call ailing the computer." But there are other ways to utilize our NFL computer picks, as well.

You can use our NFL computer as a jumping-off point to do more research into specific lines, cross-referencing with expert picks, which can be found above the selections for some matchups, recent NFL betting trends, and more.

As well, you can gauge the confidence of the matchup. The larger the projected score, the more confident the computer is in a specific pick.

Or, if you want to implement a system, betting only on underdogs, for example, you can look for matchups in which our computer likes the underdog to inform which picks you're going to hone in on for a given week.

We have these computer picks for every sport you're looking to wager on, as well:

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Moneyline

NFL moneyline picks are the simplest way to get in on the NFL action. All you have to do is simply bet on which team you think will win the game.

For moneyline picks, the favorite is represented with a minus sign (-) in front of the odds, while the underdog has a plus (+). However, you don't get the same profit for picking an underdog compared to a favorite. If the favored team is -120, a $100 bet on them would pay out $80 in profit and $180 total, if they win the game. The underdog winning at +150 would pay out a $150 profit, $250 total.

We have a complete breakdown of how to read NFL moneyline odds for these NFL computer picks.

Spread

While moneyline picks are the simplest, picking NFL games against the spread is probably the most common wager for regular NFL bettors.

To bet an NFL spread, you wager on whether a team will win by a certain number of points or more or if they'll lose by fewer points than the spread. For example, if the spread is -6.5 for the New England Patriots, you would win the bet if they win the game by 7 points or more. Or if a team is +6.5, you're betting on if they'll win outright or lose by fewer than 6.5 points.

There is a correlation between moneyline odds and the spread, as books set these lines based on the same information.

You can read more about NFL spreads here.

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If you aren’t entirely sold on which NFL team will win or cover in an NFL game, you can still use our NFL computer picks to bet on the point total.

As opposed to taking a side, in total or Over/Under betting, you wager on whether both NFL teams will combine for a final score of more than (Over) or less than (Under) the total number of points set by oddsmakers.

The computer picks, and your handicapping of totals is more about how you think both teams will score points, not which team has the edge to win.

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