Padres vs Dodgers Prediction, Picks & Odds for Tonight’s MLB Game 1

Although Dylan Cease and Yoshinobu Yamamoto have both impressed with their new teams this season, a deeper look into tonight's series opener suggests there will be plenty of offense to go around.

Kenny Ducey - Betting Analyst at Covers
Kenny Ducey • Betting Analyst
Oct 5, 2024 • 15:51 ET • 4 min read
Information icon

This article contains predictions for an old game!

Latest MLB Picks
Shohei Ohtani Los Angeles Dodgers MLB
Photo By - USA TODAY Sports

Despite a late charge up the standings, the Los Angeles Dodgers successfully held off the San Diego Padres to take the National League West crown a week ago. Now, they’ll look to fend them off once again, this time in the postseason.

Fresh off a sweep of the Atlanta Braves, the Padres will send a well-rested Dylan Cease to the hill opposite rookie Yoshinobu Yamamoto in Game 1. Despite both starters' impressive regular season numbers, my Padres vs. Dodgers predictions expect a high-scoring affair to kick off this SoCal series.

Without further ado, here's my MLB picks for Saturday, October 6. Make sure to also read our Padres vs. Dodgers prop bets!

Padres vs Dodgers prediction

My Padres vs Dodgers best bet
Over 7.5 (-115 at DraftKings)

My analysis

I could write an entire book on Dylan Cease, who’s been one of my least favorite pitchers to bet on due to his high degree of volatility. With a steady diet of walks and home runs, the San Diego Padres right-hander has been a strikeout-or-bust pitcher throughout his career.

The Los Angeles Dodgers present a nightmarish matchup for Cease, and they've historically been one of the most patient teams in the league over the last few years. L.A. is also one of the best in the league at hitting for power, and after a slight bout with strikeouts late in the year, the Dodgers reeled in those issues over the final four weeks of the year.

You couldn’t pay me enough to back Cease here, particularly given his lone postseason start lasted just 1 2/3 innings on account of some serious ineffectiveness. Dodger Stadium also isn’t an easy venue to keep the ball in the park, especially with the Dodgers' offense this hot. Away from the spacious comfort of his home park, Cease holds a 3.83 ERA, a far cry from his 3.03 ERA in San Diego.

Meanwhile, Yoshinobu Yamamoto could be in trouble against a Padres lineup that’s fared much better against fly-ball arms all year. San Diego batters boasted an excellent .213 ISO in the Wild Card round and continued its expert limitation of strikeouts at just 16.7%.

Yamamoto’s cooked in the strikeout department this year, but his middling .241 xBA should play up against a contact-oriented Padres group. I like both offenses to bring the boom tonight.

Shohei Ohtani pick: Won't Cease to Amaze

My best bet
Shohei Ohtani Over 1.5 total bases (+100 at BetMGM)

My analysis

Shohei Ohtani is 4-for-15 in his career against Cease, with three of those hits going for extra bases.

On top of that, the Dodgers superstar leads the team in total bases against “power” pitchers like Cease, hitting .298 with a .608 slugging percentage in the split. Considering Ohtani closed the year hitting above .600 in his final 10 games, he’s in store for a special postseason debut.

Padres vs Dodgers same-game parlay (SGP)

Over 7.5

Shohei Ohtani 2+ bases

Jackson Merrill 2+ total bases

The lone leg to cover here is Jackson Merrill, who went back and forth with Paul Skenes in NL Rookie of the Year odds all season. 

Finishing the final two months over .300 and racking up three hits in the two games against Atlanta, I’m all in on Merrill tonight. The young outfielder also owns a .301 average against ground-ball pitchers like Yamamoto, slugging .558 in that split.

Learn how to bet a same-game parlay with these helpful tips and strategies.

Padres vs Dodgers odds

Padres vs Dodgers live odds

Padres vs Dodgers opening odds

  • Moneyline: San Diego +120 | Los Angeles -145
  • Run line: San Diego +1.5 | Los Angeles -1.5
  • Over/Under: Over 8.0 | Under 8.0

Padres vs Dodgers moneyline and Over/Under analysis

  • The Dodgers opened as -145 favorites in Game 1 before shooting down as low as -130. The line’s settled back around -135.
  • While 46% of the bets at DraftKings are on the Padres, they’ve accounted for 60% of the handle.
  • The total was initially set at 8.0 before dipping to 7.5 on Friday night. 65% of tickets are on the Under.

Padres vs Dodgers trend

Los Angeles has hit the game total Over in 54 of its last 89 games (+19.75 Units / 20% ROI). Find more MLB betting trends for Padres vs. Dodgers.

Padres vs Dodgers Game 1 info

Location: Dodger Stadium, Los Angeles, CA
Date: Saturday, 10-5-2024
First pitch: 8:38 p.m. ET
TV: FS1
Padres starting pitcher: Dylan Cease
(14-11, 3.47 ERA)
Dodgers starting pitcher: Yoshinobu Yamamoto
(7-2, 3.00 ERA)

Padres vs Dodgers latest injuries

Padres vs Dodgers weather

Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.

Pages related to this topic

Kenny Ducey - Covers
Betting Analyst

Kenny Ducey has worked in sports media for more than 10 years and began his journey as a credentialed reporter with Fordham University's WFUV Sports before moving on to Sports Illustrated. There, he wrote about baseball, basketball, and tennis - twice covering the NBA Finals.

He's been in the betting space for seven years, and has established himself as a top expert in MLB and tennis handicapping with brands like Tennis Channel, NBC Sports, and DraftKings. He's also been a frequent guest on betting shows such as MLB's Bettor's Eye and Tennis Bets Live.

Kenny has a knack for identifying underappreciated pitchers and tennis players as moneyline underdogs and credits his unique data analysis and hours of watching sports as the biggest reasons for success through the years. His best advice to bettors? Watch the games, trust your eye, and always question the public narrative.

Popular Content

Legal Canadian sports betting

Best Canadian betting sites Ontario sports betting
Covers is verified safe by: Evalon Logo GPWA Logo GDPR Logo GeoTrust Logo Evalon Logo