76ers vs Knicks Prediction, Picks & Odds for Tonight’s NBA Game

The Knicks are favored by 13. That's not enough against the shuffling corpse of the 76ers. Expect a blowout at Madison Square Garden.

Ed Scimia - Betting Analyst at Covers.com
Ed Scimia • Betting Analyst
Apr 1, 2025 • 13:23 ET • 4 min read
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This article contains predictions for an old game!

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OG Anunoby New York Knicks NBA
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The New York Knicks will look to solidify their hold on the No. 3 seed in the Eastern Conference tonight as they host the struggling Philadelphia 76ers at Madison Square Garden.

Philadelphia has lost eight straight and doesn’t look competitive at the moment, which is why I’m taking New York to cover in my 76ers vs. Knicks predictions below.

I’ll break down everything you need to know about tonight’s game in my free NBA picks for Tuesday, April 1.

76ers vs Knicks prediction

My best bet: Knicks -13 (-110 at bet365)

My analysis
The New York Knicks initially looked like they were scrambling to hang on after Jalen Brunson went down with a sprained right ankle on March 6. However, New York has won four of its last five, and is 7-5 overall without its star point guard, showing that this is a deep roster with enough weapons to compete — at least before the playoffs — without Brunson.

That contrasts with the Philadelphia 76ers, who essentially aren’t even trying to win anymore. Philadelphia has lost eight straight, and with Joel Embiid and Paul George out for the season — not to mention the rotating list of players who have been out for games here and there over the last few weeks — there’s a severe lack of talent for the 76ers to draw from all over the court.

That’s all well and good, but bettors who want to bet on the Knicks tonight on the spread are going to have to give up a hefty 13 points, which is enough to make anyone question if the gap is actually that large. And while I stay away from lines this big in most cases, we have reason to expect a blowout.

The Knicks have won three of their last five games by 15 points or more, covering twice as a double-digit favorite. Remember, that’s all without Brunson in the lineup, so there’s no need to adjust off of that. New York is simply blowing out bad teams as it tries to stay sharp and protect its playoff seeding.

Meanwhile, Philadelphia has failed to cover as a double-digit underdog twice during its current losing streak, and five of those eight losses have come by 13+ points. The Sixers rank 27th in the NBA in defensive rating (117.4), a problem that has only gotten worse as injuries have piled up, and a clear matchup issue against a Knicks team that can score all over the court even without Brunson in the lineup.

If the Knicks were locked into their playoff position and resting their best players, I could imagine a scenario where the dregs of the Philadelphia lineup stay in this game for a while. But a motivated New York team playing at home should crush the 76ers. 

76ers vs Knicks same-game parlay

Knicks -12.5

Over 219.5

OG Anunoby Over 23.5 points

New York has been quite good on offense lately, even without Brunson in the lineup, averaging 117.8 points per game over its last five.

Both teams have had no trouble hitting the Over of late, despite their less than ideal lineups right now, so this total is lower than it should be.

The Knicks have benefited from having several capable scorers in the lineup, one of whom is OG Anunoby. He has scored at least 28 points in each of his last four games and is averaging 28.3 PPG over his last six. 

Learn how to bet a same-game parlay with these helpful tips and strategies.

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76ers vs Knicks odds

76ers vs Knicks live odds

76ers vs Knicks opening odds

  • Spread: Philadelphia +14 (-110) | New York -14 (-110)
  • Moneyline: Philadelphia +600 | New York -900
  • Over/Under: Over 223.5 (-110) | Under 223.5 (-110)

Odds courtesy of bet365

76ers vs Knicks spread and Over/Under analysis

  • The Knicks are 35-38-1 against the spread this season, while the 76ers are 26-49 ATS.
  • New York is 3-0 straight up and 2-1 ATS against Philadelphia this season.
  • Philly games are 44-29-2 to the Over. The Knicks are 39-34-1 in that direction.
  • Philadelphia is playing to an average total of 225.6 PPG, while New York has averaged 228.5 PPG this season.

76ers vs Knicks trend

The Knicks are 2-0 ATS in their last two games as double-digit favorites. Find more NBA betting trends for 76ers vs. Knicks.

How to watch 76ers vs Knicks

Location Madison Square Garden, New York, NY
Date Tuesday, 4-1-2025
Tip-off 7:30 p.m. ET
TV NBCS-Philadelphia, MSG

76ers vs Knicks latest injuries

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Ed Scimia - Covers.com
Betting Analyst

Ed Scimia has been writing about the gaming industry for over 15 years. He graduated from Syracuse University with degrees in Magazine Journalism and Political Science in 2003, and has covered major gambling events like the World Series of Poker in his career. Since joining Covers in 2022, Ed has offered his sports betting analysis primarily on MLB, NFL, college football, and college basketball games, but is willing to take on any sport.

His betting strategy focuses more on finding line value based on deviations from the market rather than traditional handicapping, primarily shopping between DraftKings, FanDuel, and Fanatics in his home state of Connecticut, though he’s not afraid to do deep game analysis to find profitable bets at any book.

Outside of gambling, Ed is an avid curler who competes in mixed doubles on the World Curling Tour and runs a popular curling YouTube channel, Chess on Ice. That experience has come in handy during the Olympics, when he has proven to be a successful curling bettor as well. 

Ed's advice to new bettors is to always open multiple sportsbook accounts and check the odds at each before placing any bet. Successful sports betting is about consistently beating the closing line value, which requires finding spots where one book is offering odds far better than the rest of the market and jumping on those opportunities.

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