Syracuse vs Pittsburgh Prediction, Picks, Odds, and Best Bet: Back the Orange in ACC Showdown

Syracuse enters Thursday night's matchup as 6.5-point underdogs against Pittsburgh, but as Ed Scimia explains below, the Orange offense is the toughest the Panthers have faced this season.

Ed Scimia - Betting Analyst at Covers.com
Ed Scimia • Betting Analyst
Oct 23, 2024 • 12:01 ET • 4 min read

NCAAF

Match starts: 29 hrs
PITT
47 %
SYR
53 %
EXPERT PICK - SPREAD
Syracuse +6.5 (-110) Syracuse +6.5 (-110)
Read Analysis
LeQuint Allen Syracuse Orange NCAAF
Photo By - Imagn Images

Two ACC teams who are on the fringes of the conference championship picture will face off on Thursday night as the Syracuse Orange visit the Pittsburgh Panthers at Acrisure Stadium.

Although the Panthers are undefeated this year, my Syracuse vs. Pittsburgh predictions expect the Orange to cover a generous spread.

Read on to see my full analysis of this key ACC matchup in my free college football picks for October 24.

Syracuse vs Pittsburgh prediction and best bet

My best bet
Syracuse +6.5 (-110 at BetMGM)
Picks made at time of writing may not reflect live odds.

My analysis

Outside of a surprising home loss for Syracuse to Stanford — a defeat that looks almost inexplicable given the rest of its results — these two teams have both been perfect on the year. Neither has been dominant, but both Syracuse and Pittsburgh are better than the average ACC squad.

This undefeated Pitt team is worthy of respect. The Panthers are putting up 481.3 yards per game on offense, averaging 7.2 yards per play — both of which are among the Top 15 in the nation.

Freshman quarterback Eli Holstein has been up to the task, throwing 15 touchdowns on the year, though he has thrown three picks in his last two games as the level of competition has increased. Pittsburgh also boasts 11 touchdowns on the ground, with Holstein joining running back Desmond Reid to create a dynamic running attack.

On the other side of the ball, most of the country is familiar with Kyle McCord’s performance behind center for the Orange. The former Ohio State quarterback has thrown for 2,160 yards and 19 touchdowns against six interceptions for Syracuse. The Orange have leaned heavily on their transfer star, as the QB has attempted at least 42 passes in each of his last five starts. 

Syracuse might be the most pass-heavy offense in the country this season, and that could pose a bit of a challenge for Pittsburgh. Opponents are averaging a solid 11.9 yards per completion and 7.0 yards per attempt against Pittsburgh, and the Syracuse passing attack is the best the Panthers will have faced this year.

I’m also skeptical of Pittsburgh based on its results against Power 4 opponents. If we ignore blowout wins against Kent State and Youngstown State, the Panthers have won their other four games by an average of just 4.3 points — including a two-point win over California at home in Week 7.

I like Syracuse more than any of the opponents Pittsburgh has played this year, and the Orange offense will certainly challenge the Panthers. This will be a close one that could go either way, and Syracuse is getting too many points to ignore.

Syracuse vs Pittsburgh same-game parlay (SGP)

Syracuse +6.5

Over 63.5

LeQuint Allen anytime touchdown

Despite a high number, I like both of these teams to score plenty on Thursday night, so I’m comfortable with taking Over 63.5.

I’m also going to back Orange running back LeQuint Allen to reach paydirt. Allen has become a focal point of the Syracuse offense lately, scoring six touchdowns in his last three contests. He’s also done so in four of six games overall this season, making him a good pick to find the end zone against Pitt.

Learn how to bet a same-game parlay with these helpful tips and strategies.

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Syracuse vs Pittsburgh odds

Syracuse vs Pittsburgh live odds

Syracuse vs Pittsburgh opening odds

  • Syracuse vs. Pittsburgh spread: Pittsburgh -3.5
  • Syracuse vs. Pittsburgh moneyline: Syracuse +170, Pittsburgh -210
  • Syracuse vs. Pittsburgh Over/Under: 60.5

Odds courtesy of BetMGM

Syracuse vs Pittsburgh spread and Over/Under analysis

  • Syracuse is 3-3 against the spread this year, while Pittsburgh enters at 5-1 ATS.
  • The Panthers are 4-2 ATS in their last six matchups against the Orange.
  • The Under has a 4-2 record in Syracuse’s games this season, while Pittsburgh has gone an even 3-3 against the total.
  • The Orange are playing to an average total of 58.5 points, while Pittsburgh is averaging an O/U of 64.3. 

Syracuse vs Pittsburgh betting trend to know

Syracuse is 2-0 SU and ATS on the road this year. Find more college football betting trends for Syracuse vs Pittsburgh.

Syracuse vs Pittsburgh game info

Location: Acrisure Stadium, Pittsburgh, PA
Date: Thursday, 10-24, 2024
Kickoff: 7:30 p.m. ET
TV: ESPN

Syracuse vs Pittsburgh latest injuries

Syracuse vs Pittsburgh weather

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Ed Scimia - Covers.com
Betting Analyst

Ed Scimia has been writing about the gaming industry for over 15 years. He graduated from Syracuse University with degrees in Magazine Journalism and Political Science in 2003, and has covered major gambling events like the World Series of Poker in his career. Since joining Covers in 2022, Ed has offered his sports betting analysis primarily on MLB, NFL, college football, and college basketball games, but is willing to take on any sport.

His betting strategy focuses more on finding line value based on deviations from the market rather than traditional handicapping, primarily shopping between DraftKings, FanDuel, and Fanatics in his home state of Connecticut, though he’s not afraid to do deep game analysis to find profitable bets at any book.

Outside of gambling, Ed is an avid curler who competes in mixed doubles on the World Curling Tour and runs a popular curling YouTube channel, Chess on Ice. That experience has come in handy during the Olympics, when he has proven to be a successful curling bettor as well. 

Ed's advice to new bettors is to always open multiple sportsbook accounts and check the odds at each before placing any bet. Successful sports betting is about consistently beating the closing line value, which requires finding spots where one book is offering odds far better than the rest of the market and jumping on those opportunities.

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