It'll soon be time to get down to brass tacks in college football, with the four major conferences working themselves out in the final weeks of the regular season.
For those hanging on, every game is a playoff game. My college football picks highlight the most important ones in the Week 12 college football odds.
College football Week 12 picks against the spread
| Matchup | Pick |
|---|---|
 Ohio State vs  Northwestern |
-28 |
 Texas vs  Arkansas |
-13 |
 Utah vs  Colorado |
+13.5 |
 Penn State vs  Purdue |
-30 |
 LSU vs  Florida |
+3.5 |
 Oregon vs  Wisconsin |
-14 |
 Tennessee vs  Georgia |
+10.5 |
 Kansas vs  BYU |
-2.5 |
Lines courtesy of DraftKings as of 11/16.
CFB Week 12 ATS picks
Ohio State (-28) vs. Northwestern: Ohio State -28
There's admittedly some fear of Ohio State looking ahead to Indiana next week, but the Buckeyes are coming off their most complete performance of the season.
Read our full Ohio State vs. Northwestern predictions.
Texas (-13) vs. Arkansas: Texas -13
A similar thought here: Texas is coming off its best game in over a month, and Arkansas is heading in the opposite direction.
Read our full Texas vs. Arkansas predictions.
Utah vs. Colorado (-13.5): Utah +13.5
Imagine telling someone before the season Colorado would be a near-two-touchdown favorite against Utah in Week 12. I'll take the points with the team that had undefeated BYU on the ropes last week.
Read our full Utah vs. Colorado predictions.
Penn State (-30) vs. Purdue: Penn State -30
Purdue did not produce one single point against Oregon or Ohio State and lost those games 80-0 all in. This shouldn't be all that different.
Read our full Penn State vs. Purdue predictions.
LSU (-3.5) vs. Florida: Florida +3.5
The wind is very much gone from LSU's sails after getting smacked by Bama and Texas A&M in the last two games, and Florida is just frisky enough to keep this close.
Read our full LSU vs. Florida predictions.
Oregon (-14) vs. Wisconsin: Oregon -14
An easy choice considering the level of play Oregon's sustained for almost two months. Helping the case is Wisconsin's 42-10 loss to... Iowa two weeks ago.
Read our full Oregon vs. Wisconsin predictions.
Tennessee (+10.5) vs. Georgia: Tennessee +10.5
Perhaps my favorite play of the bunch. There is absolutely nothing to suggest Georgia is more than 10 points better.
Read our full Tennessee vs. Georgia predictions.
Kansas vs. BYU (-3): BYU -2.5
I'll take the Cougars to stay undefeated, and avoiding the hook on the opening line of -3.5 is critical.
Read our full Kansas vs. BYU predictions.
Not intended for use in MA.
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