As the regular season winds down and conference title matchups begin to take shape, the nation's top teams must do whatever they can to avoid a late-season slip-up.
That includes Ohio State — which hosts undefeated Indiana — and Alabama, which heads to Norman to take on Oklahoma. Those matchups highlight my Week 13 college football picks below.
College football Week 13 picks against the spread
| Matchup | Pick |
|---|---|
 Indiana vs  Ohio State |
+13.5 |
 Mississippi vs  Florida |
-10 |
 Penn State vs  Minnesota |
-11.5 |
 Colorado vs  Kansas |
-2.5 |
 BYU vs  Arizona State |
+3 |
 Kentucky vs  Texas |
+21 |
 Army vs  Notre Dame |
-14.5 |
 Alabama vs  Oklahoma |
-13.5 |
Lines courtesy of DraftKings as of 11-20.
Expert CFB Week 13 ATS picks
Indiana vs. Ohio State (-13.5): Indiana +13.5
Technically a Top 5 matchup that lacks the feel of one when you lay eyes on this spread. Still, the narrative surrounding Indiana has gone a bit too far; Ohio State wins, but the Hoosiers cover.
Mississippi (-10) vs. Florida: Mississippi -10
Even if the Rebels miss the SEC title game, they have a shot at the Playoff if they look the part down the stretch. Such can't be said about Florida.
Penn State (-11.5) vs. Minnesota: Penn State -11.5
Simply put, Penn State has to dominate the rest of the way should it plan to host a Playoff game. The Nittany Lions are 2-0 ATS since losing to the Buckeyes and have exceeded expectations by an average of 12.5 points.
Colorado (-2.5) vs. Kansas: Colorado -2.5
Eight straight covers will turn to nine as the Buffs get one step closer to claiming a Big 12 title. They're simply playing too well to fade them now.
BYU vs. Arizona State (-3): BYU +3
I'm not ready to completely write off BYU after its first loss. This Cougars defense will still be the best unit on the field.
Kentucky vs. Texas (-21): Kentucky +21
This has more to do with the Wildcats — who played at Tennessee three weeks ago and lost by 10 as a 17.5-point dog — than it does about the Longhorns. Texas wins 30-13.
Army vs. Notre Dame (-14.5): Notre Dame -14.5
Despite an impressive 9-0 record, Army has bitten off more than it can chew with this game. Notre Dame rolls.
Alabama (-13.5) vs. Oklahoma: Alabama -13.5
When you combine the state of Oklahoma's offense with the state of Alabama's defense, you get a Crimson Tide-sized blowout.
Not intended for use in MA.
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