NFL Week 4 Against the Spread Picks for Every Game

Several underdogs have caught Chris Vasile's eye in Week 4, but he's kicking things off by backing the Cowboys in the Big Apple. Find out who else he's backing in this week's NFL betting picks.

Chris Vasile - Publishing Editor at Covers.com
Chris Vasile • Publishing Editor
Sep 24, 2024 • 15:29 ET • 4 min read
CeeDee Lamb Dallas Cowboys NFL
Photo By - USA TODAY Sports

Underdogs continue to dominate the headlines in the NFL as dogs of +5.5 or more are 13-1-1 ATS and 10-5 SU (h/t Jason Logan). 

This week, we've got four opportunities to back such teams, but you have to ask yourself if this is a trend you want to blindly tail this week or risk having the numbers regress to the norm. 

As we enter Week 4, we are getting an idea of each team's strengths and weaknesses, so let's look to exploit those with some sharp NFL picks.

Week 4 picks against the spread

Matchup Pick
Cowboys Cowboys vs Giants Giants Cowboys (-4.5)
Steelers Steelers vs Colts Colts Colts (+2)
Vikings Vikings vs Packers Packers
Vikings (+2.5)
Jaguars Jaguars vs Texans Texans Texans (-7)
Saints Saints vs Falcons Falcons Saints (+1.5)
Rams Rams vs Bears Bears Rams (+3)
Eagles Eagles vs Buccaneers Buccaneers Buccaneers (+2.5)
Bengals Bengals vs Panthers Panthers Bengals (-4.5)
Broncos Broncos vs Jets Jets Jets (-7)
Commanders Commanders vs Cardinals Cardinals Cardinals (-3.5)
Patriots Patriots vs 49ers 49ers 49ers (-10)
Browns Browns vs Raiders Raiders Browns (-1)
Chiefs Chiefs vs Chargers Chargers Chargers (+8)
Bills Bills vs Ravens Ravens Bills (+2.5)
Titans Titans vs Dolphins Dolphins Titans (-1)
 Seahawks Seahawks vs Lions Lions Lions (-4)

Lines courtesy of bet365 as of 9-24

Week 4 ATS picks

Cowboys vs Giants
Cowboys Cowboys -4.5

Panic may be starting to creep into the Dallas Cowboys world, but I think it's largely uncalled for. Sure, they were run off the field by a great Baltimore Ravens run game, but the Giants will offer up nothing similar. I'll take the team with the two best players on both sides of the ball. 

Steelers vs Colts
Colts Colts +2

The Steelers may be 3-0 — and the Colts may look like a JV team at times — but I don't want any part of Justin Fields on the road. The Colts run game will be the difference here and the Steelers will suffer their first loss of the season. 

Vikings vs Packers
Vikings Vikings + 2.5

I'm starting to believe in the Vikings and you should too. Sam Darnold looks rejuvenated and the defense has given up very little by way of points and third-down conversions. Malik Willis appears set to be under center once more, and I don't believe he'll continue to produce. 

Jaguars vs Texans
Texans Texans -7

The Jaguars quit on Monday Night Football and are now playing with a rest disadvantage in their second straight road game. The Texans looked bad on Sunday vs. the Vikings, but at least they have the pieces in place to bounce back in a big way. 

Saints vs Falcons
Saints Saints +1.5

The Saints played about as poorly as they could and still nearly beat the Eagles. The Falcons gave the Chiefs their best shot and came up short. I'll take the team that's less inclined to blow a lead or shoot themselves in the foot. 

Rams vs Bears
Rams Rams +3

In Caleb Williams, I do not trust. 

Eagles vs Buccaneers
Buccaneers Buccaneers +2.5

Off a bad loss, the Buccaneers should be ready to go for an Eagles side coming to town after turning the ball over four times last week (twice on downs). I have Baker Mayfield outplaying Jalen Hurts and ending the Eagles' mini resurgence. 

Bengals vs Panthers
Bengals Bengals -4.5

What's the more likely outcome? Andy Dalton shredding his former team's defense like he did the Raiders or the Bengals defense pulling their head out of their butts and helping out Joe Burrow? I'll take the team with more offensive weapons and a legitimately good quarterback. 

Broncos vs Jets
Jets Jets -7

The Broncos did well to come away with a win vs. a depleted Bucs defense, but I don't believe they'll be as lucky against Gang Green. The Jets looked good last week vs. the Patriots and with some extra rest, and a few more days to game plan, I see them pulling away late to cover this one. 

Commanders vs Cardinals
Cardinals Cardinals -3.5

Despite hanging 38 on the Bengals on MNF, I'm still not sold on the Commanders being a good team. The Cardinals battled the Lions well and I believe they'll have a game plan in place to limit Washington's weapons. 

Patriots vs 49ers
49ers 49ers -10

Reinforcements may be on the way for the 49ers and if that's the case, this number should balloon up to nearly two touchdowns. Lay the -10 and call it a day. 

Browns vs Raiders
Browns Browns +1

Spare yourself the pain and avoid watching this game at all costs. Gardner Minshew vs. Deshaun Watson is about as bad as it gets but the Browns defense should be the difference. 

Chiefs vs Chargers
Chargers Chargers +8

The Chiefs have not looked good through three games despite the 3-0 record and now take to the road for their second straight road game (laying more than a touchdown, to boot). If anything, Jim Harbaugh is a good X's and O's coach and I expect him to have a solid game plan to limit the Chiefs offense. 

Bills vs Ravens
Bills Bills +2.5

I trust Josh Allen more than I do Lamar Jackson

Titans vs Dolphins
Titans Titans -1

Would you rather back Will Levis or one of Tim Boyle or Tyler Huntley? There's probably no right answers, but the Titans put a fork in the Dolphins season on MNF. 

Seahawks vs Lions
Lions Lions -4

If you like points, this is the game for you. If you like a home team getting a cover on MNF, then take the Lions and reap the rewards! 

Not intended for use in MA.
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Chris Vasile Covers.com
Publishing Editor

Chris Vasile has been in the betting industry for well over a decade honing his craft as a writer, editor and handicapper. A journalism graduate from Conestoga College in Kitchener, Ontario, Chris has contributed betting and non-betting content for online publications such as ProSportsDaily and The Hockey Writers, in addition to Covers. With a keen interest in soccer, Chris has been featured on Covers' 'Before You Bet' and runs his own YouTube channel — Game Day Wagers.

When it comes to daily sports betting, his sportsbook of choice is bet365 for the plethora of markets and great UX. Chris' top sports betting advice is to stick to what you know. Being a jack of all trades and master of none is a quick way to bust the bankroll. Find one or two sports you can devote your time to and trust the process.

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