The San Francisco Giants host the Milwaukee Brewers in the final matchup of this four-game series at Oracle Park.
MLB odds list San Francisco as a -142 favorite ahead of first pitch, and my Brewers vs. Giants predictions expect the home favorites to prevail.
Read on for my MLB picks for Thursday, April 24.
Brewers vs Giants prediction
My Brewers vs Giants best bet: Giants moneyline (-142 at FanDuel)
Right-hander Tobias Myers makes his season debut for the Milwaukee Brewers on Thursday afternoon. Myers suffered an oblique injury that prevented him from joining the rotation at the start of the season.
While Myers put forth an impressive rookie campaign last year, his underlying metrics were far more concerning. He finished in the bottom half of the league in expected ERA (xERA), expected batting average (xBA), and barrel rate.
Myers also struggled in his lone outing against the San Francisco Giants last season, surrendering three runs in five innings en route to a 5-4 loss.
Meanwhile, right-hander Landen Roupp takes the mound for San Francisco. His analytics so far have been tremendous.
Entering this matchup, Roupp sits in the 71st percentile or higher in xERA, xBA, average exit velocity, and strikeout rate. That success could continue against Milwaukee, a team Roupp owns a 2.08 ERA against through three career meetings.
The Giants also hold the power advantage in this matchup, outranking the Brewers in slugging percentage, OPS, and home runs.
Brewers vs Giants same-game parlay (SGP)
Giants moneyline
Heliot Ramos Over 0.5 hits
Matt Chapman Over 0.5 hits
Heliot Ramos has been excellent at the plate, recording 11 hits over his past 10 games. Meanwhile, Matt Chapman has collected 10 hits over that same stretch, posting a .313 batting average.
Both Ramos and Chapman also own a .500 batting average against Myers.
Learn how to bet a same-game parlay with these helpful tips and strategies.
Brewers vs Giants odds
Brewers vs Giants live odds
Brewers vs Giants opening odds
- Moneyline: Milwaukee +120 | San Francisco -142
- Run line: Milwaukee +1.5 (-192)| San Francisco -1.5 (+160)
- Over/Under: Over 7.5 (-108) | Under 7.5 (-112)
Brewers vs Giants trend
San Francisco has ended up winning in three of Roupp’s four starts this season. Find more MLB betting trends for Brewers vs. Giants.
How to watch Brewers vs Giants and game info
| Location | Oracle Park, San Francisco, CA |
| Date | Thursday, 4-24-2025 |
| First pitch | 3:45 p.m. ET |
| TV | FanDuel Sports Network - Wisconsin, NBC Sports Bay Area |
| Brewers starting pitcher | Tobias Myers (2024: 9-6, 3.00 ERA) |
| Giants starting pitcher | Landen Roupp (2-1, 4.09 ERA) |
Brewers vs Giants latest injuries
Brewers vs Giants weather
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